Evidence map›Paper›PMID 41614178›Full record

ArticleJACS Au2026

NADH-Triggered Photogenerated Carbon Radicals as General Abstracting Agents for Synergism of Apoptosis and Ferroptosis.

Xing Zeng, Kang-Kang Yu, Hong Zhang, Yu Zhao, Ao Wang, Xu Wang, Ming-Yu Wu, Xiao-Qi Yu, Shan-Yong Chen, Kun Li

Abstract read
In one paragraph

Article in JACS Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xing ZengKey Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China.
Kang-Kang YuKey Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China.
Hong ZhangKey Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China.ORCID https://orcid.org/0009-0002-4319-5488
Yu ZhaoKey Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China.
Ao WangKey Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China.
Xu WangKey Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China.
Ming-Yu WuKey Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China.ORCID https://orcid.org/0000-0002-2047-3441
Xiao-Qi YuSichuan Provincial Engineering Research Center of Molecular Targeted Diagnostic & Therapeutic Drugs, Department of Chemistry, Xihua University, Chengdu 610064, P. R. China.ORCID https://orcid.org/0000-0003-1719-6137
Shan-Yong ChenKey Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China.
Kun LiKey Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China.ORCID https://orcid.org/0000-0002-8788-1036

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Free radicals, with their high reactivity, offer a promising strategy for tumor treatment by effectively circumventing drug resistance. Free-radical-based cancer therapies include radiotherapy, chemotherapy, and emerging approaches such as chemodynamic therapy (CDT) and photodynamic therapy (PDT). Conventional PDT, widely used in cancer treatment, relies on excited photosensitizers generating reactive oxygen species (ROS) via electron or energy transfer to kill cancer cells. However, the generation of both Type I and Type II ROS critically depends on microoxic and normoxic conditions, and the hypoxic tumor microenvironment severely limits therapeutic efficacy. Enhancing the cancer-cell-killing effect of PDT remains challenging. Herein, we constructed an S-rhodamine photosensitizer activated upon photoirradiation and NADH induction, generating a sulfur-bridged xanthene-based triarylmethyl radical (TAM

Indexed as

NADH activationphotogenerated radicaltriarylmethyl radicalxanthene

Identifiers

PMID41614178
PMCPMC12848705

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.