Evidence map›Paper›PMID 41614172›Full record

ArticleJACS Au2026

Deep-Sea Genome Mining Reveals Cooperative ATP-Grasp Ligase-Directed Biosynthesis of Pentacyclic Myxomiditides with Potent Protease Inhibition.

Yueqian Li, Jieni Wang, Zhengan Zhang, Youming Zhang, Rolf Müller, Liujie Huo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACS Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yueqian LiHelmholtz International Laboratory, State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, P. R. China.
Jieni WangHelmholtz International Laboratory, State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, P. R. China.
Zhengan ZhangHelmholtz International Laboratory, State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, P. R. China.ORCID https://orcid.org/0000-0003-3993-1163
Youming ZhangHelmholtz International Laboratory, State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, P. R. China.
Rolf MüllerHelmholtz International Laboratory, Department of Microbial Natural Products (MINS), Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) and Department of Pharmacy at, Saarland University, Campus E8 1 66123, Saarbrücken, Germany.ORCID https://orcid.org/0000-0002-1042-5665
Liujie HuoHelmholtz International Laboratory, State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, P. R. China.ORCID https://orcid.org/0000-0002-1406-8466

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microviridins are ribosomally synthesized and post-translationally modified peptides, typically featuring a conserved tricyclic structure formed by two ATP-grasp ligases. However, the diversity and evolution of these enzymes remain incompletely understood. Here, we identify a distinct ATP-grasp ligase subclade (MyxF) that specifically modifies the conserved (KxxE)

Indexed as

macrocyclizationmetagenomemicroviridinprotease-inhibitorRiPPs

Identifiers

PMID41614172
PMCPMC12848669

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.