Water-Tolerant Iminium Reactive Species for Tyrosine-Specific Functionalization.

Bivas Mondal, Lei Wang, Shirui Wang, Teck-Peng Loh

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Article in JACS Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

Bivas MondalDivision of Chemistry and Biological Chemistry, School of Chemistry Chemical Engineering & Biotechnology, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore.

Lei WangHenan Linker Technology Key Laboratory, College of Advanced Interdisciplinary Science and Technology (CAIST), Henan University of Technology, Zhengzhou 450001, China.

Shirui WangDivision of Chemistry and Biological Chemistry, School of Chemistry Chemical Engineering & Biotechnology, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore.

Teck-Peng LohDivision of Chemistry and Biological Chemistry, School of Chemistry Chemical Engineering & Biotechnology, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore.ORCID https://orcid.org/0000-0002-2936-337X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a novel, metal-free, and biocompatible method for tyrosine-specific functionalization using kinetically persistent iminium intermediates in aqueous media. By employing weakly coordinating anion-based ion-pair catalysts, this approach overcomes the inherent instability of iminium species in water, enabling efficient conjugation with phenolic compounds. The method showcases broad applicability, including the functionalization of pharmaceuticals, phenol-containing natural products, and tyrosine residues in biopolymers, all under mild and environmentally friendly conditions. Importantly, the approach preserves stereochemical integrity during biomolecule modifications and achieves high chemo- and regioselectivity. This work offers a versatile platform for biofunctionalization, with potential applications in drug discovery, therapeutic innovation, and biomolecular engineering.

Indexed as

biocompatiblebiopolymer modificationmetal-freetyrosine-specific functionalizationwater-tolerant iminiumweakly coordinating anion

Identifiers

PMID41614151

DOI10.1021/jacsau.5c01272

PMCPMC12848730

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.