Evidence map›Paper›PMID 41614131›Full record

ArticleFrontiers in microbiology2025

Gut microbiota composition correlates with insomnia severity: insights from high-throughput sequencing analysis.

Zhe Xu, Jinxia Zhang, Haifang Zhou, Lei Zhang, Xiuhong Zhang

Abstract read
In one paragraph

Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhe XuSleep Medicine Center, Hangzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Jinxia ZhangSleep Medicine Center, Hangzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Haifang ZhouDepartment of Nursing, Hangzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Lei ZhangSleep Medicine Center, Hangzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Xiuhong ZhangSleep Medicine Center, Hangzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study investigates differential alterations in gut microbiota characteristics across varying degrees of insomnia severity, aiming to provide empirical evidence elucidating the relationship between sleep disorders and the gut microbiome. Methods: A total of 120 insomnia patients, treated at the Clinical Psychology Department of Hangzhou Hospital of Traditional Chinese Medicine between October 2023 and May 2024, were enrolled and categorized into mild (Group B, Results: Alpha diversity analysis revealed significantly elevated Chao1 and ACE indices in the insomnia cohorts compared to controls ( Conclusion: Gut microbiota structure is intrinsically linked to insomnia severity, characterized by a diminished F/B ratio, reduced

Indexed as

16S rDNAgut microbiotainsomniainsomnia severitymicrobiota-gut-brain axis

Identifiers

PMID41614131
PMCPMC12851590

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.