Evidence map›Paper›PMID 41614125›Full record

ArticleFrontiers in microbiology2025

Brief early antibiotic exposure (≤2 days) is not associated with disruption of gut microbiome in very low birth weight infants.

Yoshinori Aoki, Mayumi Tate, Kayo Ochiai, Kohei Tsuchimochi, Uiko Mizuguchi, Kaoru Okazaki, Hiroshi Moritake

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yoshinori AokiFaculty of Medicine, Division of Pediatrics, University of Miyazaki, Miyazaki, Japan.
Mayumi TateFaculty of Medicine, Division of Pediatrics, University of Miyazaki, Miyazaki, Japan.
Kayo OchiaiFaculty of Medicine, Division of Pediatrics, University of Miyazaki, Miyazaki, Japan.
Kohei TsuchimochiFaculty of Medicine, Division of Pediatrics, University of Miyazaki, Miyazaki, Japan.
Uiko MizuguchiDivision of Neonatology, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.
Kaoru OkazakiDivision of Neonatology, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.
Hiroshi MoritakeFaculty of Medicine, Division of Pediatrics, University of Miyazaki, Miyazaki, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early empirical antibiotic therapy is common in preterm and very low birth weight (VLBW) infants but may disrupt the developing gut microbiome. However, the effects of brief antibiotic courses remain unclear, particularly in the most immature infants. In this prospective multicenter cohort study, we examined gut microbiome trajectories in VLBW infants (many of whom were extremely preterm) receiving no antibiotics, a short course (≤2 days), or prolonged exposure (≥3 days). Serial stool samples were analyzed using 16S rRNA gene sequencing. Microbiome composition and diversity in the short-course group were similar to those in unexposed infants at all timepoints, indicating that brief antibiotic exposure did not disrupt microbial development. In contrast, prolonged exposure was associated with transient dysbiosis characterized by reduced

Indexed as

antibiotic exposureantibiotic stewardshipBifidobacteriumgut microbiomemicrobial diversityneonatal intensive carepreterm infantsvery low birth weight infants

Identifiers

PMID41614125
PMCPMC12851591

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.