Sodium propionate modulates gut microbiota and blood parameters in healthy mice.

Wenjie Cheng, Junhong Zhu, Lanlan Yi, Guangyao Song, Yuxiao Xie, Shuailiang Che, Sumei Zhao

Abstract read

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Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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1 citing paper in PubMed.

Dihydromyricetin exerts neuroprotective effects in acute spinal cord injury by inhibiting NLRP3/Caspase-1 inflammasome through gut microbiome modeling.Journal of inflammation (London, England) · 2026
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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wenjie Cheng *Faculty of Animal Science and Technology, Yunnan Agricultural University, Kunming, China.

Junhong Zhu *Faculty of Animal Science and Technology, Yunnan Agricultural University, Kunming, China.

Lanlan YiFaculty of Animal Science and Technology, Yunnan Agricultural University, Kunming, China.

Guangyao SongFaculty of Animal Science and Technology, Yunnan Agricultural University, Kunming, China.

Yuxiao XieFaculty of Animal Science and Technology, Yunnan Agricultural University, Kunming, China.

Shuailiang CheFaculty of Animal Science and Technology, Yunnan Agricultural University, Kunming, China.

Sumei ZhaoFaculty of Animal Science and Technology, Yunnan Agricultural University, Kunming, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Short-chain fatty acids (SCFAs), particularly propionate, play crucial roles in host metabolism, immunity, and gut barrier function. However, the direct physiological effects of propionate on healthy organisms remain unclear. This study investigated the impact of sodium propionate (SP) supplementation on intestinal barrier function, gut microbiota, and hematological parameters in healthy C57BL/6 mice. Methods: Mice were orally administered 200 mg/kg SP for 21 days. Results: Results showed no significant changes in body weight, intestinal histopathology, or blood parameters. The immunohistochemical results showed decreased IL-6 expression, while IL-10 and occludin expression were increased. Gut microbiota analysis revealed decreased α-diversity in the SP group, along with shifts in microbial composition, including increased Conclusion: These findings suggest that propionate modulates gut microbiota and hematological parameters in healthy mice, providing insights into its physiological roles under normal conditions.

Indexed as

blood parametersgut microbiotahealthy micehistopathologysodium propionate

Identifiers

PMID41614124

DOI10.3389/fmicb.2025.1670591

PMCPMC12847360

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