Evidence map›Paper›PMID 41614116›Full record

ArticleResearch (Washington, D.C.)2026

NLRP3/Caspase-1 Regulate Macrophage Efferocytosis by Modulating ADAM17-Mediated MerTK Cleavage in Liver Ischemia-Reperfusion Injury.

Ge Guan, Chaoqun Yu, Longyu Miao, Tao Xiong, Yang Sun, Xiaoshuang Jin, Pengxiang Zhao, Yuerong Lu, Lisheng Wang, Peng Chen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Research (Washington, D.C.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ge GuanOrgan Transplantation Center, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Chaoqun YuDepartment of Histology and Embryology, Binzhou Medical University, Yantai, Shandong, China.
Longyu MiaoSchool of Basic Medicine, Qingdao University, Qingdao, Shandong, China.
Tao XiongDepartment of Cardiovascular Surgery, the Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, China.
Yang SunSchool of Basic Medicine, Qingdao University, Qingdao, Shandong, China.
Xiaoshuang JinSchool of Basic Medicine, Qingdao University, Qingdao, Shandong, China.
Pengxiang ZhaoSchool of Basic Medicine, Qingdao University, Qingdao, Shandong, China.
Yuerong LuSchool of Basic Medicine, Qingdao University, Qingdao, Shandong, China.
Lisheng WangSchool of Basic Medicine, Qingdao University, Qingdao, Shandong, China.
Peng ChenSchool of Basic Medicine, Qingdao University, Qingdao, Shandong, China.
Guohu DiSchool of Basic Medicine, Qingdao University, Qingdao, Shandong, China.ORCID https://orcid.org/0000-0001-9940-730X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In liver ischemia-reperfusion injury (LIRI), macrophage clearance of apoptotic cells via efferocytosis is crucial to prevent excessive inflammation and tissue damage. Here, we investigate the role of nucleotide-binding oligomerization domain-like receptor protein 3/cysteine-aspartate protease-1 (NLRP3/Caspase-1) signaling in modulating macrophage efferocytosis during LIRI. We observed robust activation of the NLRP3/Caspase-1 pathway during the early phase of LIRI. Genetic ablation of

Identifiers

PMID41614116
PMCPMC12848890

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.