Midlife short sleep with and without obesity, and the risk of future dementia: a prospective cohort study.

Hee Kyung Park, Philipp Frank, Longbing Ren, Gill Livingston, Mika Kivimaki

Abstract read

In one paragraph

Article in Wellcome open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hee Kyung ParkDivision of Psychiatry, University College London, London, 6th floor, Wing B, Maple House, W1T 7NF, UK.ORCID https://orcid.org/0000-0001-6339-0059

Philipp FrankInstitute of Epidemiology and Health Care, University College London, London, England, WC1E 7HB, UK.

Longbing RenDivision of Psychiatry, University College London, London, 6th floor, Wing B, Maple House, W1T 7NF, UK.ORCID https://orcid.org/0000-0003-2462-2421

Gill LivingstonDivision of Psychiatry, University College London, London, 6th floor, Wing B, Maple House, W1T 7NF, UK.

Mika KivimakiDivision of Psychiatry, University College London, London, 6th floor, Wing B, Maple House, W1T 7NF, UK.ORCID https://orcid.org/0000-0002-4699-5627

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Short sleep duraiton is a putative risk for dementia, whereas midlife obesity is an well-known risk factor. Midlife short sleep and obesity share some biological changes such as inflammations or metabolic changes, but their combined impact is not yet fully understood. Our aim is to investigate the associations of short leep obesity with cognitive decline and dementia risk, and to investigate whether these associations are mediated by blood markers. This is an analysis of prospective cohort study of adults who were free of dementia, had data on sleep duration and BMI at baseline in 1997-1999, and were tracked for dementia diagnoses until 2023 via linkage to electronic health records. Participants will be divided into four groups: (1) the reference group (2) short sleep (2) short sleep (≤6 hours) and non-obese weight; (3) normal sleep and obesity (≥30kg/m

Indexed as

cognitiondementianeuroinflammationobesitysleep

Identifiers

PMID41614054

DOI10.12688/wellcomeopenres.23541.2

PMCPMC12848887

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.