ArticleImaging neuroscience (Cambridge, Mass.)
Replication and validation of two novel magnetoencephalography functional connectivity measures in Alzheimer's disease.
Article in Imaging neuroscience (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Two novel magnetoencephalography (MEG) functional connectivity measures were recently shown to be superior to well-known measures of amplitude correlation and phase synchronization in detecting early stage neurophysiological abnormalities, particularly neuronal hyperexcitability, in a computational model of Alzheimer's disease (AD). The reliability of these measures in empirical data remains to be evaluated. We investigated whether the Phase Lag Time (PLT) and Joint Permutation Entropy (JPE) could identify consistent patterns of between- and within-group functional connectivity in the theta (4-8 Hz), alpha (8-13 Hz), and beta (13-30 Hz) frequency bands in eyes-closed resting-state MEG recordings from two independent cohorts of AD patients (
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