Evidence map›Paper›PMID 41613995›Full record

ArticleCase reports in medicine2026

Methotrexate-Associated Lymphoproliferative Disorders Characterized by a T-Cell Phenotype With Lung and Psoas Involvement: A Case Report.

Katsunori Arai, Hirokazu Tokuyasu, Yuriko Sueda, Hiromitsu Sakai, Hirara Watase, Mikako Yoshioka, Yoshiki Naritomi, Chika Esumi, Akira Yamasaki

Abstract read
In one paragraph

Article in Case reports in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Katsunori AraiRespiratory Medicine Division, Matsue Red Cross Hospital, Matsue, Shimane, Japan, jrc.or.jp.
Hirokazu TokuyasuRespiratory Medicine Division, Matsue Red Cross Hospital, Matsue, Shimane, Japan, jrc.or.jp.ORCID https://orcid.org/0009-0008-1727-5285
Yuriko SuedaRespiratory Medicine Division, Matsue Red Cross Hospital, Matsue, Shimane, Japan, jrc.or.jp.
Hiromitsu SakaiRespiratory Medicine Division, Matsue Red Cross Hospital, Matsue, Shimane, Japan, jrc.or.jp.
Hirara WataseRespiratory Medicine Division, Matsue Red Cross Hospital, Matsue, Shimane, Japan, jrc.or.jp.
Mikako YoshiokaRespiratory Medicine Division, Matsue Red Cross Hospital, Matsue, Shimane, Japan, jrc.or.jp.
Yoshiki NaritomiRespiratory Medicine Division, Matsue Red Cross Hospital, Matsue, Shimane, Japan, jrc.or.jp.
Chika EsumiPathology Division, Matsue Red Cross Hospital, Matsue, Shimane, Japan, jrc.or.jp.
Akira YamasakiDepartment of Multidisciplinary Internal Medicine, Division of Respiratory Medicine and Rheumatology, School of Medicine, Faculty of Medicine, Tottori University, Yonago, Tottori, Japan, tottori-u.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methotrexate (MTX) can cause MTX-associated lymphoproliferative disorders (MTX-LPDs) characterized by a T-cell phenotype. Herein, we report an extremely rare case of MTX-LPD with peripheral T-cell lymphoma (PTCL) phenotype and lung and skeletal muscle involvement. A 66-year-old man who had received MTX for 8 years for rheumatoid arthritis was admitted for right groin pain. A computed tomography scan revealed masses in the right middle lobe and right psoas muscle and multiple nodules in both lung fields. Pathological and immunohistochemical examinations of a lung nodule and psoas muscle tumor revealed PTCL. Remission was achieved soon after discontinuing MTX.

Indexed as

methotrexate-associated lymphoproliferative disorderperipheral T-cell lymphomapsoas muscle involvementremissionrheumatoid arthritis

Identifiers

PMID41613995
PMCPMC12848905

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.