Evidence map›Paper›PMID 41613962›Full record

ArticleFrontiers in endocrinology2025

The endocrine disruptor chlorpyrifos alters hypothalamic Npy and Agrp expression via ERβ-dependent regulation

Monica Pastorino, Antonella Desiderio, Erica Perrella, Michele Campitelli, Cecilia Nigro, Teresa Peluso, Mario De Felice, Concetta Ambrosino, Francesco Beguinot, Claudia Miele and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Chlorpyrifos and Chlorpyrifos-Oxon: A Widening Spectrum of Toxicity.International journal of molecular sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Monica Pastorino *Department of Translational Medicine, Federico II University of Naples, Naples, Italy.
Antonella Desiderio *Department of Translational Medicine, Federico II University of Naples, Naples, Italy.
Erica PerrellaDepartment of Translational Medicine, Federico II University of Naples, Naples, Italy.
Michele CampitelliInstitute of Endotypes in Oncology, Metabolism and Immunology, National Research Council, Naples, Italy.
Cecilia NigroInstitute of Endotypes in Oncology, Metabolism and Immunology, National Research Council, Naples, Italy.
Teresa PelusoBiogem Scarl, Institute of Molecular Biology and Genetics Research, Ariano Irpino, Italy.
Mario De FeliceDepartment of Molecular Medicine and Medical Biotechnology, Federico II University of Naples, Naples, Italy.
Concetta AmbrosinoInstitute of Endotypes in Oncology, Metabolism and Immunology, National Research Council, Naples, Italy.
Francesco BeguinotDepartment of Translational Medicine, Federico II University of Naples, Naples, Italy.
Claudia MieleInstitute of Endotypes in Oncology, Metabolism and Immunology, National Research Council, Naples, Italy.
Gregory Alexander RacitiDepartment of Translational Medicine, Federico II University of Naples, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Obesity represents a global health concern, with the hypothalamus playing a central role in regulating energy balance. Chlorpyrifos (CPF), a widely used organophosphate pesticide, is now recognized as an endocrine-disrupting chemical (EDC). Although the peripheral metabolic effects of CPF are relatively well characterized, its potential impact on central energy balance remains to be investigated. Here, we examined, both Methods: For Results: Both acute and chronic CPF exposure significantly increased Conclusion: Our findings indicate that CPF acts as a central endocrine disruptor by shifting estrogen receptor signaling toward ERβ dominance, thereby promoting orexigenic neuropeptide expression. Together with the increased

Indexed as

Agouti-Related ProteinChlorpyrifosEndocrine DisruptorsEstrogen Receptor betaGene Expression RegulationHypothalamusNeuropeptide YAnimalsCell LineFemaleMaleMiceAgouti-Related ProteinAgrp protein, mouseChlorpyrifosEndocrine DisruptorsEstrogen Receptor betaNeuropeptide Yagouti-related peptidechlorpyrifosendocrine disruptorsestrogen receptor betahypothalamusmetabolic disruptionNeuropeptide Yorexigenic neuropeptides

Identifiers

PMID41613962
PMCPMC12846974

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.