Evidence map›Paper›PMID 41613853›Full record

ArticleExtracellular vesicle2025

Neutrophil-derived extracellular vesicles in the plasma of alpha-1 antitrypsin deficient individuals reveal pro-inflammatory metabolic and transcriptomic signatures.

Zachary F Greenberg, Regina Oshins, Karina Serban, Sina F Bazargani, Timothy J Garrett, Nancy G Casanova, Joe Gn Garcia, Mei He, Nazli Khodayari

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Extracellular vesicle, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zachary F GreenbergDepartment of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, FL, USA.ORCID 0000-0001-9626-2694
Regina OshinsDepartment of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of Florida, Gainesville, FL, USA.
Karina SerbanDepartment of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of Florida, Gainesville, FL, USA.
Sina F BazarganiDepartment of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, USA.
Timothy J GarrettDepartment of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, USA.
Nancy G CasanovaThe Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, University of Florida, Jupiter, FL, USA.
Joe Gn GarciaThe Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, University of Florida, Jupiter, FL, USA.
Mei HeDepartment of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, FL, USA.
Nazli KhodayariDepartment of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of Florida, Gainesville, FL, USA.ORCID 0000-0002-4659-1622

Funding

Structure-Function Analysis of nmMLCK in EC Barrier ResponsesP01HL126609 · NHLBI · UNIVERSITY OF FLORIDA · PI Nathan A. Ellis · 2016 to 2026
$24.4M
Novel Involvement of NAMPT and TLR4 in PAH Vascular RemodelingR01HL141387 · NHLBI · UNIVERSITY OF FLORIDA · PI Joe G. N. Garcia, Ayako Makino · 2019 to 2026
$3.8M
Equipment Supplement to R35GM133794R35GM133794 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI Mei He · 2019 to 2026
$2.9M
Decay accelerating factor (CD55) protects against lectin pathway-mediated AT2 cell dysfunction in cigarette smoke-induced emphysemaR01HL166828 · NHLBI · UNIVERSITY OF FLORIDA · PI Karina Serban · 2023 to 2026
$2.8M
NHLBI NIH HHS P01 HL126609NHLBI NIH HHS R01 HL141387NHLBI NIH HHS R01 HL166828NIGMS NIH HHS R35 GM133794
6 · The paper itself

Abstract

Alpha-1 antitrypsin deficiency (AATD) is a genetic disorder caused by mutations in

Indexed as

AATDExtracellular vesiclesFunctional tissue networksMulti-OMICs

Identifiers

PMID41613853
PMCPMC12851533

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.