Evidence map›Paper›PMID 41613803›Full record

ArticleOncology research2026

Serum Extracellular Vesicle-Associated GULP1 Is a Key Indicator of Hepatocellular Carcinoma.

Hyung Seok Kim, Ju A Son, Minji Kang, Soon Sun Kim, Geum Ok Baek, Moon Gyeong Yoon, Se Ha Jang, Dokyung Jung, Ji Eun Han, Jae Youn Cheong and 1 more

Abstract read
In one paragraph

Article in Oncology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hyung Seok KimDepartment of Biochemistry, Kosin University College of Medicine, Seo-gu, Busan, 49267, Republic of Korea.
Ju A SonDepartment of Molecular Diagnostics, Ugenecell, Songpa-gu, Seoul, 05557, Republic of Korea.
Minji KangDepartment of Gastroenterology, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon, 16499, Republic of Korea.
Soon Sun KimDepartment of Gastroenterology, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon, 16499, Republic of Korea.
Geum Ok BaekDepartment of Gastroenterology, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon, 16499, Republic of Korea.
Moon Gyeong YoonDepartment of Gastroenterology, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon, 16499, Republic of Korea.
Se Ha JangDepartment of Gastroenterology, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon, 16499, Republic of Korea.
Dokyung JungDepartment of Molecular Medicine, Kyungpook National University School of Medicine, 680 Gukchaebosang-ro, Daegu, 41944, Republic of Korea.
Ji Eun HanDepartment of Gastroenterology, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon, 16499, Republic of Korea.
Jae Youn CheongDepartment of Gastroenterology, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon, 16499, Republic of Korea.
Jung Woo EunDepartment of Gastroenterology, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon, 16499, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Early detection of hepatocellular carcinoma (HCC) is a significant challenge due to the limited sensitivity of alpha-fetoprotein (AFP). This study aimed to assess serum-derived extracellular vesicle-encapsulated GULP PTB domain-containing engulfment adaptor 1 ( Methods: The study utilized both internal and external cohorts of HCC patients and controls. Small EVs were isolated from serum samples, then characterized and validated to confirm their identity. The expression levels of Results: Conclusion: These findings highlight

Indexed as

Adaptor Proteins, Signal TransducingBiomarkers, TumorCarcinoma, HepatocellularExtracellular VesiclesLiver Neoplasmsalpha-FetoproteinsFemaleHumansMaleMiddle AgedPrognosisAdaptor Proteins, Signal Transducingalpha-FetoproteinsBiomarkers, TumorbiomarkerExtracellular vesiclesGULP PTB domain-containing engulfment adaptor 1hepatocellular carcinomaliquid biopsy

Identifiers

PMID41613803
PMCPMC12848681

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.