Evidence map›Paper›PMID 41613761›Full record

ArticleChemical & biomedical imaging2026

A Caspase-3-Activatable Near-Infrared AIEgen for Tumor Apoptosis Imaging In Vivo.

Lingling Xu, Yuanyuan Jin, Zhanjun Yang, Wenjun Zhan, Gaolin Liang, Shurong Shen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical & biomedical imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lingling XuBreast Surgery, Wenzhou Central Hospital, Wenzhou 325000, China.
Yuanyuan JinSchool of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China.
Zhanjun YangSchool of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China.ORCID https://orcid.org/0000-0002-6963-9633
Wenjun ZhanBreast Surgery, Wenzhou Central Hospital, Wenzhou 325000, China.ORCID https://orcid.org/0000-0002-5552-1298
Gaolin LiangBreast Surgery, Wenzhou Central Hospital, Wenzhou 325000, China.ORCID https://orcid.org/0000-0002-6159-9999
Shurong ShenBreast Surgery, Wenzhou Central Hospital, Wenzhou 325000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Near-infrared (NIR) fluorescence imaging of tumor caspase-3 activity can be applied for real-time monitoring of the therapeutic effect of an anticancer drug in vivo. Aggregation-induced emission luminogens (AIEgens) are highly sensitive, unique fluorophores, but there is no NIR AIEgen reported for the above purpose. Herein, we rationally developed an activatable NIR AIEgen, Ac-Asp-Glu-Val-Asp-Pra-QMT (

Indexed as

AIEgenscaspase-3in vivo imagingnear-infraredtumor apoptosis

Identifiers

PMID41613761
PMCPMC12848816

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.