ArticleCureus2025
An Uncommon Reaction to a Very Common Drug: Hydrochlorothiazide-Induced Pulmonary Edema.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-cardiogenic pulmonary edema is a rare but serious adverse reaction to hydrochlorothiazide. We present a case report of a patient who developed severe dyspnea and hypoxemic respiratory failure within 30 minutes of the first hydrochlorothiazide dose. Management consisted of supportive care, oxygen therapy, and avoidance of thiazide diuretics, consistent with prior reports. This case emphasizes the importance of recognizing hydrochlorothiazide-induced non-cardiogenic pulmonary edema as a rare but life-threatening adverse event, the limitations of relying solely on biomarkers such as procalcitonin, and the need for careful documentation to prevent re-exposure.
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Registered trials
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