Evidence map›Paper›PMID 41613623›Full record

ArticleFrontiers in cellular neuroscience2025

Early transcriptomic perturbations highlight the spinal cord as a key pathogenic region in spinocerebellar ataxia type 3.

Jacen Emerson, Brianna S Nelthrope, Emma A Walker, Grace Mao, Hannah K Shorrock, Hayley S McLoughlin

Abstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jacen EmersonDepartment of Neurology, University of Michigan, Ann Arbor, MI, United States.
Brianna S NelthropeThe RNA Institute and Department of Biological Sciences, College of Arts & Sciences, University at Albany-SUNY, Albany, NY, United States.
Emma A WalkerDepartment of Neurology, University of Michigan, Ann Arbor, MI, United States.
Grace MaoDepartment of Neurology, University of Michigan, Ann Arbor, MI, United States.
Hannah K ShorrockThe RNA Institute and Department of Biological Sciences, College of Arts & Sciences, University at Albany-SUNY, Albany, NY, United States.
Hayley S McLoughlinDepartment of Neurology, University of Michigan, Ann Arbor, MI, United States.

Funding

Nonneuronal Mechanisms of Polyglutamine NeurodegenerationR01NS122751 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MCLOUGHLIN, HAYLEY S · 2021 to 2025
$2.2M
Interrogating the necessity of neuronal contributions to SCA3F31NS145373 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jacen Emerson · 2025 to 2026
$88k
NINDS NIH HHS F31 NS145373NINDS NIH HHS R01 NS122751
6 · The paper itself

Abstract

Spinocerebellar ataxia type 3 (SCA3) is a neurodegenerative disease caused by polyglutamine repeat expansion in the

Indexed as

alternative splicinginflammationoligodendrocytepolyglutamine (polyQ) diseaseSCA3spinal cordspinocerebellar ataxia

Identifiers

PMID41613623
PMCPMC12846992

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.