ArticleFrontiers in cellular and infection microbiology2025
The pathological correlation between pulmonary tuberculosis and sarcoidosis patients and the impact of presence of nodules on pulmonary tuberculosis patients.
Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Both pulmonary tuberculosis (PTB) and sarcoidosis (SA) are chronic, systemic, granulomatous diseases. Due to their similar clinical and radiological features, as well as similar pathological characteristics, it is difficult to distinguish. This study aims to explore the pathological correlation between PTB and SA and the impact of nodules formation on the occurrence of PTB. Methods: We retrospective enrolled 307 patients admitted to the tuberculosis department between January 2022 and March 2024. After applying the inclusion and exclusion criteria, 170 patients were divided into three groups and analyzed: sarcoid tuberculosis group (TB-N, n=59), non-sarcoid tuberculosis group (TB-NoN, n=74), and sarcoidosis group (SA, n=37). Comparative analysis was performed on the clinical characteristics, pathogen profiles, and pulmonary microbial composition differences among the three groups. Results: Patients in the TB-N and SA group predominantly presented with multiple nodules. Among samples testing positive by both mNGS and conventional microbiological tests (CMT), the proportion of partially matched results was higher in the TB-N group than in the TB-NoN group, with a greater diversity of pathogenic bacteria detected in the TB-N group. ACE index analysis revealed significantly higher microbial richness in the TB-NoN group compared to both SA and TB-N groups. Regarding treatment regimens, combination therapy was more frequently administered in the TB-N group, while single drug treatment predominated in the TB-NoN group. Although the duration of anti-tuberculosis treatment was longer in the TB-N group, this difference did not reach statistical significance. Discussion: Significant differences in imaging manifestations were observed between TB-N and SA groups. The presence of nodules was associated with a more complex pathogen profile in PTB patients; however, the pulmonary microbial diversity was lower in TB-N than in TB-NoN. PTB patients with nodules predominantly received combination therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.