Evidence map›Paper›PMID 41613587›Full record

ArticleFrontiers in physiology2025

Direct simulation of hypertensive stress on endothelial cells: a streamlined model of in-vitro-hypertension.

Elena Raschi, Caterina Bodio, Chiara Brullo, Gianfranco Parati, Pier Luigi Meroni, Maria Orietta Borghi, Laura Calvillo

Abstract read
In one paragraph

Article in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elena Raschi *Immunorheumatology Research Laboratory, IRCCS Istituto Auxologico Italiano, Milan, Italy.
Caterina Bodio *Immunorheumatology Research Laboratory, IRCCS Istituto Auxologico Italiano, Milan, Italy.
Chiara BrulloDepartment of Pharmacy, Section of Medicinal Chemistry, University of Genova, Genova, Italy.
Gianfranco ParatiDepartment of Cardiology, Istituto Auxologico Italiano IRCCS, Milan, Italy.
Pier Luigi MeroniImmunorheumatology Research Laboratory, IRCCS Istituto Auxologico Italiano, Milan, Italy.
Maria Orietta Borghi *Immunorheumatology Research Laboratory, IRCCS Istituto Auxologico Italiano, Milan, Italy.
Laura Calvillo *Department of Cardiology, Istituto Auxologico Italiano IRCCS, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypertension stands as one of the most significant preventable risk factors for cardiovascular disease, which is the leading cause of mortality worldwide. There is a disturbing gap, in preclinical research, between simplified cell culture and complex

Indexed as

3RsAngiotensin IIbioreactordynamic culturehuman umbilical vein endothelial cellshypertensionLive-Pamillifluidic in-vitro technology

Identifiers

PMID41613587
PMCPMC12847034

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.