ReviewFundamental research2025
Gene circuit-based sensors.
Review in Fundamental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Applications of synthetic biology in biomedicine.Molecular biomedicine · 2026Review
- Traceless Regulation of Genetic Circuitry.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Nano-synthetic biology for disease diagnosis and treatment.Fundamental research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As an important branch of biosensors, gene circuit-based biosensors constructed based on synthetic biology concepts can sense specific substances to be measured and converted into specific signal outputs. Such sensors have great potential in the fields of biomanufacturing process monitoring, environmental monitoring, food safety, medical diagnosis, and monitoring. With the development of synthetic biology technology and the abundance of genetic components, more and more cell-free microbial sensors with different response mechanisms, logic gates, and logic loops have been developed. This review integrates the basic concepts of synthetic biology to comprehensively describe the design and engineering of synthetic biology gene circuits, an overview of synthetic biology based on cell-free systems (CFS), and the development of biosensors based on CFS. Emphasis is placed on the design concepts, construction principles, and applications of cell-free-based biosensors in the field of bioassay. We also discuss the new frontiers in the field and the challenges to be addressed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.