ReviewFundamental research2025
DNA-based hydrogels: Ideal biomaterials for cartilage organoids.
Review in Fundamental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Design and Characterization of DX-Tile DNA Nanostar-Based Hydrogels.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- EXO/hydrogel system for sequential regulation of endogenous hyaline cartilage regeneration.Materials today. Bio · 2025Article
- Hydrogels as advanced drug delivery platforms for cancer immunotherapy: promising innovations and future outlook.Journal of nanobiotechnology · 2025Review
- Accelerating cartilage regeneration with DNA-SF hydrogel sustained release system-based cartilage organoids.Military Medical Research · 2025Article
- DNA-encoded dynamic hydrogels for 3D bioprinted cartilage organoids.Materials today. Bio · 2025Review
- Silk fibroin-based hydrogels for cartilage organoids in osteoarthritis treatment.Theranostics · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoarthritis (OA) is a common degenerative disease with high disability rate, imposing significant economic burdens on individuals and society. Due to the limited self-repair ability of articular cartilage, the existing treatment methods still cannot effectively treat OA. Organoids are multicellular structures differentiated from stem cells or organ progenitors and can be used to model disease. Future applications can provide alternative organ replacement strategies. Therefore, constructing cartilage organoids is expected to overcome the shortcomings of the existing treatment methods to achieve effective treatment of OA. The construction of organoids requires three-dimensional network scaffolds resembling extracellular matrix (ECM) to support cell expansion. Hydrogel has a hydrophilic natural network structure. Hence it can mimic the ECM, providing mechanical support and a favorable microenvironment for cell growth. DNA hydrogel is mainly formed by DNA. It preserves DNA's programmability, biocompatibility and biodegradability, and has unique mechanical properties. Thus, it is an ideal material for constructing cartilage organoids. This review summarized the preparation methods and discussed the use of DNA hydrogels in the construction of cartilage organoids, aiming to provide a reference for the construction and design of cartilage organoids based on DNA hydrogels.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.