ReviewFundamental research2025
Supramolecular macrocyclic artificial ion channels for biomedical applications.
Review in Fundamental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- An Artificial Anion Channel Based on Supramolecular Calix[4]Pyrrole and Its Application as an Anti-Cancer Agent.Chemistry, an Asian journal · 2026Article
- Nano-synthetic biology for disease diagnosis and treatment.Fundamental research · 2025Article
- Rational Design of Supramolecular Receptors for Consistent Binding Affinities under High-Salinity Conditions.The Journal of organic chemistry · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biological ion channels are essential for ion and molecule transport, playing a critical role in maintaining cellular equilibrium and regulating vital physiological functions such as cell growth, hormone secretion, and nerve-muscle interactions. Drawing inspiration from nature, researchers have crafted an array of supramolecular artificial ion channels (AICs) using both unimolecular and self-assembly approaches. Notably, AICs based on macrocyclic molecules, such as cyclodextrins, crown ethers, and pillararenes, offer distinct advantages, including biocompatibility, precise structural design, ease of customization, and simple preparation. This review spotlights recent progress in bioinspired AICs rooted in macrocycles and their applications in the realm of biomedicine. We commence with an overview of the significance of biological channels and the strategies employed for fashioning supramolecular artificial channels. Subsequently, we navigate through the intricate landscape of molecular design, structural modulation, and the ion transport prowess exhibited by macrocycle-based AICs. Furthermore, we explore the promising biomedical applications of these AICs, encompassing roles in antibacterial measures, anticancer interventions, biosensing technologies, and treatments for channelopathies. Finally, we address the persisting challenges and illuminate prospects within this field, with the ultimate aim of steering future innovations in the development of supramolecular AICs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.