Evidence map›Paper›PMID 41613416›Full record

ArticlemicroPublication biology2026

A Novel Cell-Cell Communication Structure: Tanycyte and Cilia Hypothalamic Unifying Glia-cilia Structure (HUGS).

Kara R Schwantz, Jaelyn G Boone, Kathryn M Brewer, Nicolas F Berbari

Abstract read
In one paragraph

Article in microPublication biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kara R SchwantzBiology, Indiana University Indianapolis, Indianapolis, Indiana, United States.
Jaelyn G BooneBiology, Indiana University Indianapolis, Indianapolis, Indiana, United States.
Kathryn M BrewerBiology, Indiana University Indianapolis, Indianapolis, Indiana, United States.
Nicolas F BerbariDepartment of Biology, Indiana University Indianapolis, Indianapolis, Indiana, United States.

Funding

How Hedgehog Contributes to Centrally Mediated Energy Homeostasis?R01DK114008 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Nicolas F Berbari, Jeremy F Reiter · 2018 to 2026
$3.3M
Cilia-mediated Proliferation in Hypothalamic TanycytesF31DK142351 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Kathryn M Brewer · 2025 to 2026
$82k
NIDDK NIH HHS F31 DK142351NIDDK NIH HHS R01 DK114008
6 · The paper itself

Abstract

Primary cilia, microtubule-based sensory organelles that mediate cell-cell communication, may facilitate signaling in the brain through direct physical contacts (e.g., synapse-like structures). Similarly, specialized glial cells lining the third ventricle (3V) called tanycytes signal through physical interactions and can dynamically alter their morphology in response to external stimuli and physiological changes. Here, we identify robust cilia-tanycyte contacts; we term HUGS ( H ypothalamic, U nifying G lia-cilia S tructures) and discover that these connections are disrupted in a mouse ciliopathy model (

Identifiers

PMID41613416
PMCPMC12848617

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.