Evidence map›Paper›PMID 41613377›Full record

ArticleFrontiers in pediatrics2025

Prevalence and early-life risk factors of asthma in preterm adolescents: a cohort study.

Nienke H van Dokkum, Arend F Bos, Sijmen A Reijneveld, Elianne J L E Vrijlandt

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Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Nienke H van DokkumDivision of Neonatology, Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Arend F BosDivision of Neonatology, Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Sijmen A ReijneveldDepartment of Health Sciences, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Elianne J L E VrijlandtDivision of Pulmonology, Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: We seek to elucidate the prevalence, types of respiratory symptoms experienced, and potential early-life risk factors of asthma in adolescence. Methods: We performed a prospective cohort study including 294 adolescents [130 moderately-late preterm (MLP), 81 early preterm (EP), and 83 full-term (FT)]. Asthma, asthma-like symptoms, and smoking in early childhood and adolescence were self-reported. We collected prenatal and postnatal characteristics, including maternal smoking, bronchopulmonary dysplasia, and respiratory syncytial virus (RSV) infections. Results: In 11% of EP, 4% of MLP, and 4% of FT adolescents, a formal asthma diagnosis was made. Asthma-like symptoms were reported in 14%, 14%, and 7% of the cases, respectively. Being hospitalized for an RSV infection was associated with a four times higher risk of asthma in adolescence (odds ratio 3.68 and 95% confidence interval 1.04-13.0), while other predictors did not contribute. Conclusion: MLP adolescents have similar rates of asthma and asthma-like symptoms as their FT peers, while EP adolescents might have a higher risk of asthma but have similar rates of asthma-like symptoms. RSV infections that require hospitalization are associated with an asthma diagnosis in adolescence. Clinical Trial Registration: https://www.controlled-trials.com, identifier ISRCTN 80622320.

Indexed as

adolescenceasthmaepidemiologyprematurityrisk factors

Identifiers

PMID41613377
PMCPMC12847436

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