SynthesisFrontiers in medicine2025
Efficacy and safety of Kangaroo mother care vs. conventional care during hospitalization for preterm and/or low birth weight infants: a meta-analysis with trial sequential analysis of randomized controlled trials.
Synthesis in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Kangaroo mother care (KMC) plays a significant role in reducing mortality among preterm or low birth weight (LBW) infants. However, comprehensive evidence regarding various clinical outcomes during hospitalization for neonates receiving KMC remains limited. This meta-analysis focuses on hospital-based KMC and aims to evaluate its efficacy and safety for neonates during their hospital stay. Methods: A systematic search of the literature was undertaken across major databases, including PubMed, Web of Science, Embase, and the Cochrane Library, to identify randomized controlled trials (RCTs) published up to July 9, 2025. Binary outcomes were analyzed using risk ratio (RR), while continuous data were assessed using standardized mean difference (SMD) or mean difference (MD), each reported with corresponding 95% confidence intervals (CIs). To evaluate heterogeneity among studies, the Cochrane Results: This meta-analysis synthesized data from 31 RCTs, encompassing 8561 preterm and/or LBW infants. The findings of this meta-analysis indicated that compared with conventional care, KMC significantly reduced in-hospital mortality [RR (95% CI) = 0.791 (0.696-0.899), 95% PI: 0.679-0.925] and 28-day all-cause mortality [RR (95% CI) = 0.810 (0.709-0.926), 95% PI: 0.605-1.085]. Furthermore, KMC was associated with shorter duration of hospitalization [MD (95% CI) = -0.809 (-1.601, -0.017), 95% PI: -3.219, 1.601] and notable improvements in growth parameters, including accelerated weight gain, increased length growth, and enhanced head circumference growth during the hospital stay (all Conclusion: KMC is a clinically effective and safe intervention for the management of preterm and/or LBW neonates. Present evidence highlights its role in reducing neonatal mortality, expediting hospital discharge, fostering growth and developmental outcomes, as well as mitigating the incidence of complications. Moreover, the benefits of this intervention are particularly significant in lower-middle-income countries.
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