ArticleFrontiers in chemistry2025
GC-MS-based metabolic profiling of essential oils from
Article in Frontiers in chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Chemical composition and insecticidal activity of Salvia rosmarinus 'Eretto Liguria' essential oil against tomato leaf miner (Tuta absoluta).Scientific reports · 2026Article
- Chemical and enantioselective GC-MS characterization ofFrontiers in pharmacology · 2026Article
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Abstract
Introduction: Plant-derived essential oils (EOs) are rich sources of bioactive compounds, some of which exhibit acetylcholinesterase (AChE) inhibitory activity and may offer therapeutic potential for the management of Alzheimer's disease (AD). This study aimed to evaluate the chemical composition and AChE inhibitory potential of essential oils extracted from C Methods: Essential oils were obtained by hydrodistillation and analyzed using gas chromatography-mass spectrometry (GC-MS) to identify their chemical constituents. AChE inhibitory activity was determined using Ellman's colorimetric assay, and IC Results: A total of 63 metabolites were identified across the three essential oils, accounting for approximately 90% of their total composition. Grapefruit EO was predominantly composed of limonene (89.94%), henna EO was rich in phytol (41.42%) and limonene (23.02%), while sadab EO was characterized by 1-hexadecanol acetate (26.39%) and phytol (20.54%). Grapefruit EO exhibited the strongest AChE inhibitory activity (IC Discussion: The notable AChE inhibitory activity observed in grapefruit and henna essential oils is likely attributable to their high terpenoid content. These findings suggest that selected plant-derived essential oils may represent promising natural candidates for the prevention or management of neurodegenerative disorders such as Alzheimer's disease.
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