Evidence map›Paper›PMID 41613221›Full record

ReviewRSC advances2026

Nanobiotechnology-driven advances in sonodynamic therapy: unlocking the potential of sonosensitizers in clinical translation.

Zhaokui Zeng, Tian Tian, Jia Liu, Letian Bai, Jun Zhang, Changhong Nie, Bo Liu, Chuanpin Chen, Wei Lu

Abstract readReview
In one paragraph

Review in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Method for Isolating Hypericin fromMolecules (Basel, Switzerland) · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhaokui ZengSchool of Pharmaceutical Sciences, Jishou University Jishou 416000 China.
Tian TianDepartment of Pharmacy, Xiangya School of Pharmaceutical Sciences, Central South University Changsha 410000 China ccpin2000@hotmail.com.
Jia LiuDepartment of Pharmacy, Xiangya School of Pharmaceutical Sciences, Central South University Changsha 410000 China ccpin2000@hotmail.com.
Letian BaiDepartment of Pharmacy, Xiangya School of Pharmaceutical Sciences, Central South University Changsha 410000 China ccpin2000@hotmail.com.
Jun ZhangDepartment of Pharmacy, Xiangya School of Pharmaceutical Sciences, Central South University Changsha 410000 China ccpin2000@hotmail.com.
Changhong NieDepartment of Pharmacy, Xiangya School of Pharmaceutical Sciences, Central South University Changsha 410000 China ccpin2000@hotmail.com.
Bo LiuDepartment of General Surgery, The Second Xiangya Hospital, Central South University Changsha 410000 China.
Chuanpin ChenDepartment of Pharmacy, Xiangya School of Pharmaceutical Sciences, Central South University Changsha 410000 China ccpin2000@hotmail.com.ORCID https://orcid.org/0000-0001-8094-1270
Wei LuDepartment of Cardiovascular Surgery, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital Quzhou 324000 China luwei@wmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sonodynamic therapy (SDT) is an emerging, non-invasive modality to cancer treatment, notable for its ability to overcome the limited tissue penetration of photodynamic therapy (PDT) while delivering enhanced precision and reduced adverse effects. This distinctive advantage has positioned SDT as a highly compelling approach within the biomedical landscape. Central to the success of SDT is the development of sonosensitizers, whose design and functionality critically influence therapeutic efficacy. This review discussed the fundamental principles and mechanism of SDT. It highlighted recent advances in nanobiotechnology-based sonosensitizers, including inorganic sonosensitizers, organic sonosensitizers, inorganic-organic hybrid sonosensitizers and other sonosensitizers, and also indicated the specific designs and potential challenges of sonosensitizers. Furthermore, this review outlined the obstacles that need to be overcome for the successful clinical translation and application of SDT. In conclusion, SDT represents a promising strategy for cancer therapy, with sonosensitizers expected to play a pivotal role in integrating diagnostics, enhancing drug delivery, and enabling multimodal treatment approaches.

Identifiers

PMID41613221
PMCPMC12848502

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.