ArticleJDS communications2025
Transcriptomic changes induced by controlled cyclical heat stress in the bovine mammary gland during lactation.
Article in JDS communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Supplementation of Rumen-Protected Methionine to Heat-Stressed Transition Cows Impacts Mammary Gland Cell Dynamics and Gene Expression.Animals : an open access journal from MDPI · 2026Article
- Single-nucleus RNA sequencing reveals cell type-specific responses to heat stress in bovine mammary gland.Journal of animal science and biotechnology · 2026Article
- Heat Stress Effects on Milk Production and the Genomic Architecture of Thermotolerance in Dairy Cattle.Biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study examined the effects of heat stress (HS) on mid-lactating (100 ± 14 DIM) Holstein cows. Cows were assigned to either HS (temperature-humidity index [THI] 74-80; n = 7) or thermoneutral (pair-fed PFTN; THI 64; n = 8) conditions for 4 d. Exposure to HS reduced milk (4.34 ± 1.62 kg/d), protein (0.18 ± 0.04 kg/d), and fat (0.18 ± 0.05 kg/d) yields, highlighting the negative impacts of HS on production and homeostasis. To explore main molecular responses, mammary gland tissue samples were collected for transcriptomic analysis. Transcriptomic analysis revealed 54 upregulated and 74 downregulated genes in HS conditions. Upregulated genes included heat shock proteins (
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.