Ultra-processed food intake and impairment across multiple cognitive domains in nationally representative older U.S. adults.

Introduction: Ultra-processed food (UPF) consumption, which accounts for more than 50% of energy intake in the U.S., has steadily increased among older adults over the past decade. UPF consumption is associated with overall cognitive decline, but few studies have examined the associations between UPF consumption and individual cognitive domains. In this study, we examined associations between UPF consumption and impairment in executive function, memory, language, visuospatial, and orientation using data from the longitudinal and nationally representative Health and Retirement Study (HRS). Methods: Data were drawn from HRS participants who took part in both the 2013 Health Care and Nutrition Study (HCNS) and the 2016 Harmonized Cognitive Assessment Protocol (HCAP) and who did not have dementia or memory problems at baseline (2012) ( Results: In the analytic sample, mean UPF intake was 42.3% energy/day. After adjustment for baseline sociodemographic and health characteristics, higher UPF consumption showed a marginally significant trend toward greater impairment in executive function (Q4 vs. Q1, OR 2.08, 95% CI 1.16-3.74; Q5 vs. Q1, OR 1.73, 95% CI 0.97-3.09; P-trend = 0.052). UPF consumption was not significantly associated with impairment in other cognitive domains. Discussion: Our findings highlight a potential association between high UPF intake and executive functioning impairment among older U.S. adults.