ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Willing, but unequally: Indigenous identity influences participation in Alzheimer's disease biomarker research in Chile.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Examining the Decision to Take a Dementia Risk Test: Considerations for Privacy in Screening At-Home.Dementia and geriatric cognitive disorders · 2026Article
- Introduction to the special issue on ethics and equity in implementing novel biomarkers for Alzheimer's disease and related dementias: current progress and new directions.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Willing, but unequally: Indigenous identity influences participation in Alzheimer's disease biomarker research in Chile.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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6 authors.
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Abstract
introductionThis study aimed to compare the willingness to use Alzheimer's disease (AD) predictive-diagnostic procedures between Mapuche (Indigenous) and non-Indigenous older adults in Chile.
methodsWe conducted a cross-sectional study including Mapuche (
resultsOverall willingness was high, except for cerebrospinal fluid testing (39.1%). In fully adjusted models, Mapuche participants were significantly less willing to undergo neuropsychological assessment (77.8% vs. 92.3%), blood testing (68.3% vs. 89.9%), and brain imaging (73.1% vs. 84.3%). Key determinants of willingness varied by ethnic group and included age, sex, AD-related worry, social determinants, and number of dementia risk factors. DISCUSSION: Despite high overall willingness, ethnic identity and psychosocial factors significantly influenced receptiveness to AD predictive-diagnostic procedures. Highlights: Indigenous populations in high-income countries face a higher risk of dementia, making Alzheimer's disease (AD) biomarker and diagnostic research a critical priority in these groups.Despite this, Indigenous and Latin American populations remain among the most underrepresented in dementia research.In a sample of Indigenous (Mapuche) and non-Indigenous older adults in Chile, most participants reported willingness to use AD biomarkers and diagnostic procedures.In fully adjusted models, Mapuche individuals were significantly less willing to undergo neuropsychological testing, blood tests, and brain imaging for AD risk prediction.Willingness to use AD biomarkers varied by ethnic identity and was influenced by age, social determinants, and attitudes toward AD.
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