Evidence map›Paper›PMID 41613003›Full record

ReviewFrontiers in molecular biosciences2025

Origin of the clock in

Ahmad Al-Omari, Cara Altimus, Jonathan Arnold, Sam Arsenault, Suchendra Bhandarkar, Shishir Bhusal, Christian Caranica, Jia Hwei Cheong, Zhaojie Deng, Arthur S Edison and 13 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in molecular biosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Ahmad Al-OmariBiomedical Systems and Informatics Engineering Department, Yarmouk University, Irbid, Jordan.
Cara AltimusScience Philanthropy Accelerator for Research and Collaboration (SPARC), Milken Institute, Washington, DC, United States.
Jonathan ArnoldComplex Carbohydrate Research Center, University of Georgia, Athens, GA, United States.
Sam ArsenaultDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, MASS, United States.
Suchendra BhandarkarDepartment of Computer Science, University of Georgia, Athens, GA, United States.
Shishir BhusalDepartment of Physics and Astronomy, University of Georgia, Athens, GA, United States.
Christian CaranicaCenter for Theoretical Biological Physics, Northeastern University, Boston, MASS, United States.
Jia Hwei CheongComplex Carbohydrate Research Center, University of Georgia, Athens, GA, United States.
Zhaojie DengRarecyte, Seattle, WA, United States.
Arthur S EdisonComplex Carbohydrate Research Center, University of Georgia, Athens, GA, United States.
Garrett FloydDepartment of Physics and Astronomy, University of Georgia, Athens, GA, United States.
James GriffithComplex Carbohydrate Research Center, University of Georgia, Athens, GA, United States.
Brooke HullDepartment of Molecular Biology, Princeton University, Princeton, NJ, United States.
Michael T JudgeImperial College, London, United Kingdom.
Yang LiuCollege of Engineering, University of Georgia, Athens, GA, United States.
Leidong MaoCollege of Engineering, University of Georgia, Athens, GA, United States.
Bijoy MohantyComplex Carbohydrate Research Center, University of Georgia, Athens, GA, United States.
Xiao QiuUS Clinical Pharmacology and Pharmacometrics Department, Johnson and Johnson, Spring House, PA, United States.
H-B SchüttlerDepartment of Physics and Astronomy, University of Georgia, Athens, GA, United States.
Ashley ScruseCenter for Broadening Participation in Computing, Morehouse College, Atlanta, GA, United States.
Thiab TahaDepartment of Computer Science, University of Georgia, Athens, GA, United States.
Lingyun WuDepartment of Physics and Astronomy, University of Georgia, Athens, GA, United States.
Yue WuDepartment of Genetics, Stanford University, Stanford, CA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We examine the collective behavior of single cells in microbial systems to provide insights into the origin of the biological clock. Microfluidics has opened a window onto how single cells can synchronize their behavior. Four hypotheses are proposed to explain the origin of the clock from the synchronized behavior of single cells. These hypotheses depend on the presence or absence of a communication mechanism between the clocks in single cells and the presence or absence of a stochastic component in the clock mechanism. To test these models, we integrate physical models for the behavior of the clocks in single cells or filaments with new approaches to measuring clocks in single cells. As an example, we provide evidence for a quorum-sensing signal both with microfluidics experiments on single cells and with continuous

Indexed as

biological clockcontinuous in vivo metabolism NMRcoupled oscillatorsensemble methodsmicrofluidicsquorum sensingstochastic coherencestochastic resonance

Identifiers

PMID41613003
PMCPMC12848316

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.