Evidence map›Paper›PMID 41612900›Full record

ArticleAlcohol, clinical & experimental research2026

Comparative multi-omics in female mice reveals tissue-specific vulnerabilities to chronic alcohol intake.

Craig R G Willis, Muni Swamy Ganjayi, Austin M Brown, Samantha E Moser, Nathaniel J Szewczyk, Brian C Clark, Cory W Baumann

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Alcohol, clinical & experimental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Craig R G WillisResearch Software and Analytics, University of Exeter, Exeter, UK.ORCID https://orcid.org/0009-0002-0433-2144
Muni Swamy GanjayiDepartment of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA.ORCID https://orcid.org/0000-0002-0007-5630
Austin M BrownDepartment of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA.
Samantha E MoserHonors Tutorial College, Ohio University, Athens, Ohio, USA.
Nathaniel J SzewczykDepartment of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA.ORCID https://orcid.org/0000-0003-4425-9746
Brian C ClarkDepartment of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA.ORCID https://orcid.org/0000-0002-6021-6431
Cory W BaumannDepartment of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA.ORCID https://orcid.org/0000-0002-2457-1911

Funding

Neuronal mechanisms involved in aging and ADR01AG067758 · NIA · OHIO UNIVERSITY ATHENS · PI ARNOLD, WILLIAM DAVID, CLARK, BRIAN C · 2021 to 2025
$4.1M
Neural mechanisms of dynapeniaR01AG044424 · NIA · OHIO UNIVERSITY ATHENS · PI CLARK, BRIAN C · 2014 to 2018
$1.4M
NIA NIH HHS R01 AG044424NIA NIH HHS R01 AG067758NIH HHS R01AG044424NIH HHS R01AG067758Osteopathic Heritage FoundationUK Research and InnovationUniversity of Exeter's Project ADA
6 · The paper itself

Abstract

backgroundAlcohol-related liver disease (ALD) and alcohol-related myopathy are consequences of chronic alcohol use. However, understanding of the associated molecular mechanisms and effective treatments remains limited.

methodsMulti-omics were employed to uncover molecular blueprints of liver versus skeletal muscle responses to chronic alcohol exposure, using a preclinical mouse model showing signs of alcohol-related liver dysregulation (diminished liver phosphatidylcholine-to-phosphatidylethanolamine lipid ratio) and alcohol-related myopathy (reduced muscle mass and strength).

resultsA greater proportion of transcriptomic, proteomic, and metabolomic features were altered by alcohol in liver than muscle, whereas similar proportions of lipid species were affected in both tissues. The liver was significantly enriched for a broad and diverse set of metabolic pathways across molecular layers, while muscle was associated with upregulated inflammatory and matrisome responses and impaired mitochondrial energetics. Lipidome analyses also revealed a novel potential role for altered phospholipid remodeling in the etiology of alcohol-related myopathy. Finally, computational drug repurposing identified several compounds for therapeutic targeting of alcohol-induced liver (e.g., saracatinib, GSK126) and muscle (e.g., metformin, trichostatin A) pathophysiology.

conclusionsOverall, this study provides a list of therapeutic targets and treatments to help expedite the understanding of and countermeasures against ALD and myopathy in humans.

Indexed as

Alcohol DrinkingEthanolLiverLiver Diseases, AlcoholicMuscle, SkeletalAnimalsFemaleLipid MetabolismLipidomicsMetabolomicsMiceMice, Inbred C57BLMultiomicsOrgan SpecificityProteomicsTranscriptomeEthanolalcohollipidomicslivermetabolomicsmulti‐omicsproteomicsskeletal muscletranscriptomics

Identifiers

PMID41612900
PMCPMC12856532

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.