ArticleClinical oral implants research2026
Immunohistological Evaluation of Peri-Implant Soft Tissue Grafting Using a Porcine Dermal Matrix-A Human Histological Study.
Article in Clinical oral implants research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionThe aim was the immunohistological evaluation of a porcine dermal matrix (PDM) in comparison to a non-augmented control group for peri-implant tissue thickening. MATERIALS AND
methodsThis human histological study involved the placement of PDM in the test group (20 patients) during implant placement, while the control group underwent implant placement without grafting (20 patients). Postoperative clinical evaluations were conducted, and biopsies were obtained after 3 months. Histomorphometric evaluation utilized H&E staining. Immunohistological analysis included CD31, PSR, TE-7, CD3, CD20, CD138, and CD68.
resultsA total of 40 patients (17 females, 23 males; 60.62 years) were included. Though more frequent gingival redness occurred during wound healing in the PDM, the groups showed no significant differences in epithelial thickness (p = 0.63), rete ridges (p = 0.53), papilla density (p = 0.626), papilla complexity (p = 0.053), vascularization (p = 0.052), connective tissue morphology (p = 0.127), collagen differentiation (p = 0.41), and CD3
conclusionThe PDM used in this study exhibited no significant differences regarding epithelial changes, vascularization, tissue morphology, and collagen differentiation compared to a healthy control sample 3 months after grafting. The PDM group demonstrated a significantly higher frequency of CD68
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