Evidence map›Paper›PMID 41612804›Full record

Trial reportBrain and behavior2026

Corticomotor Excitability Changes Induced by Progressive Balance Exercises in Chronic Ankle Instability: a Randomized Clinical Trial.

Mahdis Purzolfi, Cyrus Taghizadeh Delkhoush, Majid Mirmohammadkhani

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mahdis PurzolfiDepartment of Physical Therapy, School of Rehabilitation Sciences, Semnan University of Medical Sciences, Semnan, Iran.
Cyrus Taghizadeh DelkhoushDepartment of Physical Therapy, School of Rehabilitation Sciences, Semnan University of Medical Sciences, Semnan, Iran.ORCID https://orcid.org/0000-0001-9275-961X
Majid MirmohammadkhaniSocial Determinants of Health Research Center, Semnan University of Medical Sciences, Semnan, Iran.

Funding

Semnan University of Medical SciencesSemnan University of Medical Sciences and Health Services 2093
6 · The paper itself

Abstract

backgroundProgressive balance exercises may change corticomotor excitability during the learning process of postural stability control. The primary purpose of the present study was to assess corticomotor excitability corresponding to the peroneus longus muscle under transcranial magnetic stimulation following 6 weeks of progressive balance exercises in individuals with chronic ankle instability.

methodsEligible volunteers diagnosed with chronic ankle instability were randomly assigned to either the intervention group or the control group. The intervention group practiced progressive balance exercises every other day for 6 weeks, while the control group continued their daily activities. The corticomotor excitability outcome measures included the active and resting corticomotor thresholds, the motor evoked potential, and the cortical silent period of the peroneus longus muscle, which were measured using an electromyography device under a transcranial magnetic stimulator. The outcome measures were measured in the intervention group before and after progressive balance exercises, and in the control group at baseline and again after a 6-week interval.

resultsThe corticomotor thresholds and cortical silent period of the peroneus longus muscle were significantly decreased within groups (p-values < 0.001; η

conclusionsSix weeks of progressive balance exercises significantly increased corticomotor excitability corresponding to the peroneus longus muscle in individuals with chronic ankle instability.

Indexed as

AnkleEvoked Potentials, MotorExercise TherapyJoint InstabilityMotor CortexPostural BalanceAdultAnkle JointChronic DiseaseElectromyographyFemaleHumansMaleMuscle, SkeletalTranscranial Magnetic StimulationYoung Adultankle spraincortical excitabilitymotor evoked potentialtranscranial magnetic stimulation

Identifiers

PMID41612804
PMCPMC12856227

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.