SynthesisBrain and behavior2026
Prevention of Postoperative Delirium in Patients Undergoing Elective Surgery Using Multicomponent Interventions: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Synthesis in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevention of Postoperative Delirium in Patients Undergoing Elective Surgery Using Multicomponent Interventions: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Brain and behavior · 2026Pooled it
- Long-Term Cognitive and Functional Outcomes of Anesthesia and Surgery in Patients with Dementia.Healthcare (Basel, Switzerland) · 2026Review
- Association between the unaccompanied nursing care model and postoperative delirium in older adults with hip fractures: a retrospective before-and-after cohort study.Frontiers in medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and hypothesisPostoperative delirium (POD) is a common acute cognitive disorder among older adults following elective surgery. It prolongs hospitalization, increases the risk of complications and readmission, and may contribute to long-term cognitive decline, thereby reducing patients' quality of life. Although various preventive strategies have been developed, single interventions often yield limited efficacy. This study systematically evaluates, through meta-analysis, the effectiveness of multicomponent interventions in preventing POD among older adults undergoing elective surgery. STUDY
designA systematic search was conducted in PubMed, Embase, Web of Science, and the Cochrane Library for randomized controlled trials (RCTs) published through July 2025. Risk ratios (RRs) with 95% confidence intervals (CIs) were calculated to assess intervention effects, and pooled analyses were performed using a random-effects model. STUDY
resultsEleven RCTs comprising 3857 patients undergoing elective surgery were included in the final analysis. Multicomponent interventions significantly reduced POD incidence in older adults (RR: 0.71; 95% CI: 0.59-0.85; p < 0.001), representing a 29% risk reduction. Between-study heterogeneity was low (I
conclusionsMulticomponent interventions are effective in reducing POD incidence in older adults undergoing elective surgery, with geographical variation influencing effect size. These findings support broader clinical adoption of such interventions for POD prevention.
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Registered trials
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