ArticleJournal of breast cancer2026
Prognostic Evaluation of the Charlson Comorbidity Index for Breast Cancer Patients by Propensity Score Matching Analysis.
Article in Journal of breast cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Prenatal tobacco exposure and adult offspring brain health: the mediating role of leukocyte telomere length in a large population-based cohort.Translational psychiatry · 2026Article
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17 authors.
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Abstract
purposeThe Charlson Comorbidity Index (CCI) is associated with the prognosis of patients with breast cancer. However, comorbidities are often confounded by both age and treatment course; therefore, it is essential to eliminate the influence of these factors. We analyzed the relationship between CCI scores and breast cancer prognosis using propensity score matching (PSM).
methodsWe retrospectively analyzed 1,403 patients with primary breast cancer who underwent curative surgery. After PSM, 764 patients were selected for analysis of clinicopathological and prognostic factors.
resultsAfter PSM, prognosis was compared between groups according to several CCI cutoff values. No significant differences in disease-free survival or breast cancer-specific overall survival (OS) were observed according to the CCI score. Similarly, no significant differences in OS were observed between the high- and low-CCI groups at CCI cutoff values of 1 and 2. However, at a CCI cutoff value of 3, OS was significantly worse in patients with higher CCI scores.
conclusionAmong patients with breast cancer, those with CCI scores ≥ 3 often experience mortality due to diseases other than breast cancer.
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