ArticlePsychological medicine2026
The role of altered decision dynamics and dorsolateral prefrontal cortex to amygdala causal circuitry in the aberrant efficacy of emotion suppression in subthreshold depression.
Article in Psychological medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Unveiling state-specific neural dynamics in migraine with and without depressive symptom: a hidden Markov model and interpretable machine learning approach.The journal of headache and pain · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIndividuals with subthreshold depression (StD), a potentially preclinical stage of major depression, may habitually employ maladaptive expression suppression strategies in emotion regulation. However, the effect of emotional suppression (EES) and underlying neural mechanisms remain unclear.
methodsData came from two samples (Sample 1: 55 StD, 60 healthy controls (HC); Sample 2: 23 StD, 20 HC). Both samples completed expression suppression tasks. Using drift diffusion modeling, we decomposed performance on the emotional assessment process into separate processing components, particularly the speed of information update (drift rate), to examine how depression and emotional suppression affect decision-making. To further reveal the potential mechanism, we conducted fMRI scanning in Sample 2 and characterized latent neurocircuit driving emotion suppression and drift rate using dynamic causal modeling (DCM).
resultsThe EES negatively correlated with drift rate. StD showed reduced efficacy of EES and faster drift rates of negative preference. Greater activation was observed in the dorsolateral prefrontal cortex (dlPFC) and amygdala in StD during suppression. DCM analysis revealed that inefficient EES might be explained by the stronger connection from the right dlPFC to the right amygdala, while the faster drift rate might be attributed to a stronger connection from the left amygdala to the right dlPFC.
conclusionsOur study uncovered novel latent behavioral and neurocircuit mechanisms of early risk for depression. Ineffective emotional suppression in StD is associated with faster accumulation of negative evidence. The underlying neural mechanism may involve aberrant regulation between the dlPFC and amygdala in negative contexts.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.