ArticleAdvanced healthcare materials2026
Zinc-Containing Bioactive Glass Programs Macrophage Polarization through Extracellular Traps Regulation for Enhanced Diabetic Wound Healing.
Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Compartment-specific Zinc Misallocation in Diabetic Foot Ulcers: Mechanistic Coupling Between Macrophage M1 Locking and MMP-9 Hyperactivation.Biological trace element research · 2026Review
- Mitochondrial DNA regulation of hepatic ischemia-reperfusion injury and intervention strategies.Journal of translational medicine · 2026Review
- Regenerative Therapies for Cosmetic Dermatology for Patients with Diabetes Mellitus: Skin Aging, Aesthetic Concerns, and Evidence-Based Best Practices.International journal of molecular sciences · 2026Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Impaired diabetic wound healing is driven by immune dysregulation and microenvironmental disruptions induced by hyperglycemia, leading to excessive inflammation and defective macrophage polarization. Although macrophage extracellular traps (METs) play critical roles in chronic inflammatory diseases, their involvement in shaping the diabetic wound immune microenvironment and impeding macrophage polarization remains insufficiently understood. Here, we present zinc-containing bioactive glass (ZnBG), in which zinc incorporation confers immunomodulatory properties. In a type 2 diabetic full-thickness skin excision model, ZnBG significantly mitigates MET-associated oxidative stress and inflammation. Mechanistic investigations reveal that ZnBG effectively suppresses MET formation by reducing reactive oxygen species levels, inhibiting PAD4 activation, and blocking the NLRP3/caspase-1/GSDMD signaling pathway. Consequently, ZnBG facilitates macrophage transition from the pro-inflammatory M1 phenotype to the reparative M2 phenotype in diabetic wounds, thereby alleviating inflammation, enhancing neovascularization, and ultimately promoting diabetic wound healing. These findings provide an innovative therapeutic strategy that integrates ZnBG with targeted modulation of macrophage function for the treatment of diabetic wounds.
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Registered trials
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