Evidence map›Paper›PMID 41612558›Full record

Observational studyJournal of neurotrauma2026

Alterations in CSF Amyloid-β and Tau Biomarkers in Former College and Professional American Football Players: Findings from the DIAGNOSE CTE Research Project.

Deidre Jansson, Jane Shofer, Elizabeth Colasurdo, Abigail Schindler, Ge Li, Charles H Adler, Laura Balcer, Charles Bernick, Daniel Daneshvar, Douglas Katz and 15 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of neurotrauma, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Deidre JanssonVISN 20 Northwest Mental Illness Research, Education and Clinical Center (MIRECC), VA Puget Sound Health Care System, Seattle, Washington, USA.
Jane ShoferDepartment of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA.
Elizabeth ColasurdoVISN 20 Northwest Mental Illness Research, Education and Clinical Center (MIRECC), VA Puget Sound Health Care System, Seattle, Washington, USA.
Abigail SchindlerVISN 20 Northwest Mental Illness Research, Education and Clinical Center (MIRECC), VA Puget Sound Health Care System, Seattle, Washington, USA.
Ge LiVISN 20 Northwest Mental Illness Research, Education and Clinical Center (MIRECC), VA Puget Sound Health Care System, Seattle, Washington, USA.
Charles H AdlerDepartment of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA.
Laura BalcerDepartments of Neurology, Population Health and Ophthalmology, NYU Grossman School of Medicine, New York, New York, USA.
Charles BernickCleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, Nevada, USA.
Daniel DaneshvarDepartment of Physical Medicine and Rehabilitation Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Douglas KatzBoston University CTE Center, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Michael McCleanEncompass Health Braintree Rehabilitation Hospital, Braintree, Massachusetts, USA.
Jesse MezBoston University Alzheimer's Disease Research Center, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Joseph PalmisanoBiostatistics and Epidemiology Data Analytics Center (BEDAC), Boston University School of Public Health, Boston, Massachusetts, USA.
Nicholas AshtonDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Kaj BlennowDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Yorghos TripodisBoston University CTE Center, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Michael L AloscoBoston University CTE Center, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Jeffrey L CummingsChambers-Grundy Center for Transformative Neuroscience; Department of Brain Health, Kirk Kerkorian School of Medicine, University of Nevada Las Vegas, Las Vegas, Nevada, USA.
Eric M ReimanBanner Alzheimer's Institute, University of Arizona, Arizona State University, Translational Genomics Research Institute, and Arizona Alzheimer's Consortium, Phoenix, Arizona, USA.
Martha ShentonPsychiatry Neuroimaging Laboratory, Harvard Medical School, Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Robert A SternBoston University CTE Center, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Jeffrey IliffVISN 20 Northwest Mental Illness Research, Education and Clinical Center (MIRECC), VA Puget Sound Health Care System, Seattle, Washington, USA.
Elaine R PeskindVISN 20 Northwest Mental Illness Research, Education and Clinical Center (MIRECC), VA Puget Sound Health Care System, Seattle, Washington, USA.
DIAGNOSE CTE Research Project

Funding

Chronic Traumatic Encephalopathy: Detection, Diagnosis, Course, and Risk FactorsU01NS093334 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CUMMINGS, JEFFREY L., REIMAN, ERIC MICHAEL · 2016 to 2022
$17.0M
Risk and Resilience, Clinical presentation, and Biomarker Profiles of Chronic Traumatic Encephalopathy and Related Dementias: The DIAGNOSE CTE Research Project IIR01NS139383 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Michael Alosco, Nicholas Ashton · 2024 to 2026
$9.3M
Role of Sleep Disruption after mTBI as a Driver of Chronic Post-traumatic HeadacheR01NS129573 · NINDS · SEATTLE INST FOR BIOMEDICAL/CLINICAL RES · PI Jeffrey J Iliff, Andrew F Russo · 2023 to 2026
$2.4M
NINDS NIH HHS R01 NS129573NINDS NIH HHS R01 NS139383NINDS NIH HHS U01 NS093334
6 · The paper itself

Abstract

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with exposure to repetitive head impacts (RHIs), characterized by tau tangles around small blood vessels at the depths of the sulci. Currently, CTE can be diagnosed only

Indexed as

Amyloid beta-PeptidesAthletesChronic Traumatic EncephalopathyFootballtau ProteinsAgedBiomarkersHumansMaleMiddle AgedPhosphoproteinsAmyloid beta-PeptidesBiomarkersPhosphoproteinstau ProteinsAbeta 40Abeta 42biomarkerscerebrospinal fluidchronic traumatic encephalopathyhyperphosphorylated taurepetitive head impactstotal tautraumatic encephalopathy syndrome

Identifiers

PMID41612558
PMCPMC13130387

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.