Evidence map›Paper›PMID 41612541›Full record

ReviewJournal of the Chinese Medical Association : JCMA2026

Potential therapeutic role of calcitonin gene-related peptide medications for tinnitus.

Abigail Dichter, Khushi Bhatt, Martha Lucía Gutiérrez Pérez, Ella J Lee, Karen Tawk, Hamid R Djalilian

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of the Chinese Medical Association : JCMA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Abigail DichterDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, USA.
Khushi BhattDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, USA.
Martha Lucía Gutiérrez PérezDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, USA.
Ella J LeeDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, USA.
Karen TawkDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, USA.
Hamid R DjalilianDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tinnitus is defined as the perception of sound without an external stimulus. It is classified as a subjective phenomenon described as ringing, buzzing, or hissing in the ears. Tinnitus often co-occurs with migraine, as both conditions originate from disturbances of the central nervous system, specifically the auditory and trigeminal nerve pathways. The overlap in populations and pathophysiological similarities between tinnitus and migraine provide strong evidence for overlap between the conditions and a shared potential for therapy. Calcitonin gene-related peptide (CGRP) medications are a recent development in migraine treatment that have proven to be effective prophylactic agents. CGRP medications work by blocking CGRP's inflammatory role in migraine formation, a physiological process that may also be involved in the loudness of tinnitus. This narrative review aims to provide an overview of the role of CGRP in migraine and tinnitus and discuss managing CGRP and central sensitization as a potential therapeutic role in tinnitus.

Indexed as

Calcitonin Gene-Related PeptideTinnitusHumansMigraine DisordersCalcitonin Gene-Related PeptideCalcitonin gene-related peptideCentral sensitizationMigraineTinnitusTrigeminal nerve

Identifiers

PMID41612541
PMCPMC13004237

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.