Evidence map›Paper›PMID 41612479›Full record

Trial reportTrials2026

Improving outcomes in adult patients who self-harm-evaluating a brief psychological intervention in emergency departments (ASSURED): protocol of a randomised controlled clinical trial.

Rose McCabe, Mimi Suzuki, Sally O'Keeffe, Neil Walker, Richard Hooper, Stefan Priebe, Borislava Mihaylova, Yan Feng, Chris Dickens, Peter Aitken and 11 more

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Trials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Rose McCabeSchool of Health and Psychological Sciences, City St George's, University of London, London, UK.
Mimi SuzukiSchool of Health and Psychological Sciences, City St George's, University of London, London, UK.
Sally O'KeeffeFaculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Neil WalkerPragmatic Clinical Trials Unit, Queen Mary University of London, London, UK.
Richard HooperPragmatic Clinical Trials Unit, Queen Mary University of London, London, UK.
Stefan PriebeSchool of Health and Psychological Sciences, City St George's, University of London, London, UK.
Borislava MihaylovaPragmatic Clinical Trials Unit, Queen Mary University of London, London, UK.
Yan FengPragmatic Clinical Trials Unit, Queen Mary University of London, London, UK.
Chris DickensUniversity of Exeter, Exeter, UK.
Peter AitkenUniversity of Exeter, Exeter, UK.
Vera Araújo SoaresDivision of Prevention, Center for Preventive Medicine and Digital Health (CPD), Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
Richard ByngUniversity of Plymouth, Plymouth, UK.
Domenico GiaccoUniversity of Warwick, Warwick, UK.
Navneet KapurUniversity of Manchester, Manchester, UK.
Will LeeUniversity of Exeter, Exeter, UK.
Peter RiouRoyal Devon University Healthcare NHS Foundation Trust, Exeter, UK.
Mary RyanSchool of Health and Psychological Sciences, City St George's, University of London, London, UK.
Alan SimpsonKing's College London, London, UK.
Helen SmithUniversity Hospitals Plymouth NHS Trust, Plymouth, UK.
Lucy Polyanna GoldsmithSchool of Health and Psychological Sciences, City St George's, University of London, London, UK.
Alexandra Elissavet BakouSchool of Health and Psychological Sciences, City St George's, University of London, London, UK. alexandra.bakou@citystgeorges.ac.uk.ORCID http://orcid.org/0000-0002-4813-7212

Funding

National Institute for Health and Care Research RP-PG-0617-20004NIHR Applied Research Collaboration (ARC) North East and North Cumbria NIHR200173
6 · The paper itself

Abstract

backgroundPatients with self-harm and suicidal ideation are increasingly presenting in emergency departments (ED) in the UK. Self-harm is the strongest risk factor for suicide. Currently, there are no evidence-based interventions for self-harm offered in the context of general hospitals in the UK. This trial, funded by the National Institute for Health and Care Excellence (NIHR), aims to assess the clinical and cost-effectiveness of the ASSURED intervention. The ASSURED intervention includes up to five rapid follow-up contacts, comprising a narrative interview and enhanced safety planning session and three solution-focused sessions. The trial is sponsored by Devon Partnership NHS Trust and City St George's, University of London.

methodsASSURED is a multicentre, two-arm, parallel-group, individually randomised, controlled trial comparing the ASSURED intervention with usual care. The primary outcome is whether study participants re-attend ED and are referred to liaison psychiatry within 18 months from the date of randomisation. Secondary outcomes include suicidality, self-reported self-harm, psychological wellbeing, social outcomes, experiences of attending the ED, and suicide. The study will also evaluate the cost-effectiveness of the intervention. The aim of this study was to recruit and randomise 620 patients across 14 acute hospital sites in London, Devon, Somerset, and the Midlands. Participants are invited to complete research assessments at baseline and 3, 9, and 18 months. The first participant was enrolled in the study in August 2022, and the recruitment target was met in December 2024. DISCUSSION: This will be the first UK trial to test the effectiveness and cost-effectiveness of a rapid intervention for patients presenting to EDs with self-harm and suicidal ideation and has the potential to improve outcomes for these patients.

trial registrationISRCTN 13472559. Registered on 18 of November 2021.

Indexed as

Emergency Service, HospitalPsychotherapy, BriefSelf-Injurious BehaviorAdultClinical ProtocolsCost-Benefit AnalysisCost-Effectiveness AnalysisEmergency Room VisitsHealth Care CostsHumansResearch DesignSuicidal IdeationSuicide PreventionTime FactorsTreatment OutcomeEmergency departmentNarrative interviewingNon-suicidal self-injuryProtocolPsychological interventionRandomised controlled clinical trialSafety planSelf-harmSolution-focused brief therapySuicidal ideation

Identifiers

PMID41612479
PMCPMC12930565

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.