ArticleBMC oral health2026
Application of a chlorinated catechol monomer to enhance dentin bond durability and impart antibacterial activity.
Article in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesTo synthesize a novel chlorinated catechol monomer, N-(2-chloro-4,5-dihydroxyphenethyl) methacrylamide (Cl-DMA), and evaluate its efficacy as a primer in enhancing dentin bond durability and imparting antibacterial properties.
methodsCl-DMA at varying concentrations (0, 1, 3, and 5 wt%) dissolved in 50% DMSO/H₂O were applied as primer agent to dentin surfaces for 60 s. The interaction between Cl-DMA with type I collagen was assessed by ATR-FTIR and molecular docking. The effects of Cl-DMA primers on dentin bond strength and durability were comprehensively evaluated using degree of conversion (DC), micro-tensile bond strength (µTBS) test, fracture pattern observation, nanoleakage evaluation, and in situ zymography analysis. The antibacterial properties of Cl-DMA were assessed through colony forming unit (CFU) counting, CCK-8 assay, crystal violet staining, scanning electron microscopy (SEM) observation, and live/dead bacterial fluorescence staining. The assessment of Cl-DMA-induced cytotoxicity was performed by measuring cell viability with a CCK-8 kit and fluorescence staining.
resultsCl-DMA potentially interacted with type I collagen via hydrogen bond. Pretreatment with Cl-DMA solutions effectively maintained resin-dentin bond strength, preserved stability of the bonded interface, and inhibited endogenous protease activity. Antibacterial effects against Streptococcus mutans biofilm formation and bactericidal capacity improved gradually with increasing Cl-DMA concentration. Cl-DMA was well-tolerated by the cells compared with Bis-GMA, with no observed cytotoxicity at doses up to 50 µg/mL.
conclusionsPretreating dentin surface with Cl-DMA primer for 60 s can effectively stabilize the bonded interface and exhibit significant antibacterial efficacy.
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