Evidence map›Paper›PMID 41612336›Full record

ArticleJournal of nanobiotechnology2026

CD8a antibody-functionalized biomimetic red blood cell membrane ectosomes delivering C646 reverse CD8⁺ T Cell exhaustion via H3K18la histone delactylation in gastric cardia adenocarcinoma.

Zheng Xiang, Xinxin Zhang, Xinlei Liu, Xiaohu Lv, Yubo Hu, Chi Zhang, Chunlei Zou, Anqi Wang, Bo Zhang, Wei Wang and 2 more

Abstract read
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zheng Xiang *Department of Oncology, The Second Affiliated Hospital of Bengbu Medical University, No. 633 Longhua Road, Huaishang District, 233000, Bengbu, China.
Xinxin Zhang *Department of General Surgery, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, Shanghai, 201800, China.
Xinlei LiuDepartment of Oncology, The Second Affiliated Hospital of Bengbu Medical University, No. 633 Longhua Road, Huaishang District, 233000, Bengbu, China.
Xiaohu LvDepartment of Oncology, The Second Affiliated Hospital of Bengbu Medical University, No. 633 Longhua Road, Huaishang District, 233000, Bengbu, China.
Yubo HuDepartment of Oncology, The Second Affiliated Hospital of Bengbu Medical University, No. 633 Longhua Road, Huaishang District, 233000, Bengbu, China.
Chi ZhangDepartment of Oncology, The Second Affiliated Hospital of Bengbu Medical University, No. 633 Longhua Road, Huaishang District, 233000, Bengbu, China.
Chunlei ZouDepartment of Oncology, The Second Affiliated Hospital of Bengbu Medical University, No. 633 Longhua Road, Huaishang District, 233000, Bengbu, China.
Anqi WangShanghai Key Laboratory for Cancer Systems Regulation and Clinical Translation, Shanghai, 201800, China.
Bo ZhangDepartment of General Surgery, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, Shanghai, 201800, China.
Wei WangDepartment of Oncology, The Second Affiliated Hospital of Bengbu Medical University, No. 633 Longhua Road, Huaishang District, 233000, Bengbu, China. wangwei@bbmu.edu.cn.
Guodong CaoDepartment of General Surgery, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Anhui Province, 230000, Hefei, China. 11718242@zju.edu.cn.
Jianguang JiaDepartment of Oncology, The Second Affiliated Hospital of Bengbu Medical University, No. 633 Longhua Road, Huaishang District, 233000, Bengbu, China. Jiajianguang1978@126.com.

Funding

Anhui Provincial Clinical Key Specialty Construction Project No. 025Anhui Provincial Health Commission Key Research Project No. AHWJ2023A10093National Natural Science Foundation of China No. 82403333Natural Science Key Project of Anhui Provincial Education Department No. 2024AH051217
6 · The paper itself

Abstract

The functional exhaustion of CD8

Indexed as

AdenocarcinomaCD8 AntigensCD8-Positive T-LymphocytesCell-Derived MicroparticlesHistonesStomach NeoplasmsAnimalsBiomimetic MaterialsCell Line, TumorFemaleHumansMiceProgrammed Cell Death 1 ReceptorT-Cell ExhaustionTumor MicroenvironmentCD8 AntigensHistonesProgrammed Cell Death 1 ReceptorC646Gastric cardia adenocarcinomaH3K18laProgrammed cell death protein 1Red blood cell membrane-derived ectosomes

Identifiers

PMID41612336
PMCPMC12895709

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.