Evidence map›Paper›PMID 41612310›Full record

Trial reportBMC medicine2026

How effective is rejoining a long-term weight loss program? The 5- and 10-year MRI-assessed Follow Interventions Trial (FIT) project.

Hadar Klein, Dafna Pachter, Dana Tamar Goldberg Toren, Omer Kamer, Liav Alufer, Noa Ebstein Karamani, Yoash Chassidim, Ilan Shelef, Assaf Rudich, Uri Yoel and 13 more

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01530724 phase3completednot on this map

Effect of Weight-loss Diet Strategies and Exercise on Dynamics of Body Fat Depots and Metabolic Rate

TypeinterventionalSponsorBen-Gurion University of the NegevRan2012 to 2014Enrolled224ConditionsObesityArmsWeight-loss diet strategy (+) exercise (PA), weight loss (-) exercise (PA)
NCT03020186 nacompletednot on this map

Effects of Green-MED Diet Via the Gut-fat-brain Axis; DIRECT-PLUS

TypeinterventionalSponsorBen-Gurion University of the NegevRan2017 to 2019Enrolled294ConditionsAbdominal Obesity Metabolic SyndromeArmsPhysical activity, Physical activity+ MED diet, Physical activity+green MED diet
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Hadar KleinDepartment of Epidemiology, Biostatistics and Community Health Sciences, Faculty of Health Sciences, School of Public Health, The Health and Nutrition Innovative International Research Center, Ben-Gurion University of the Negev, P.O. Box 653, Beer-Sheva, 8410501, Israel.
Dafna PachterDepartment of Epidemiology, Biostatistics and Community Health Sciences, Faculty of Health Sciences, School of Public Health, The Health and Nutrition Innovative International Research Center, Ben-Gurion University of the Negev, P.O. Box 653, Beer-Sheva, 8410501, Israel.
Dana Tamar Goldberg TorenDepartment of Epidemiology, Biostatistics and Community Health Sciences, Faculty of Health Sciences, School of Public Health, The Health and Nutrition Innovative International Research Center, Ben-Gurion University of the Negev, P.O. Box 653, Beer-Sheva, 8410501, Israel.
Omer KamerDepartment of Epidemiology, Biostatistics and Community Health Sciences, Faculty of Health Sciences, School of Public Health, The Health and Nutrition Innovative International Research Center, Ben-Gurion University of the Negev, P.O. Box 653, Beer-Sheva, 8410501, Israel.
Liav AluferDepartment of Epidemiology, Biostatistics and Community Health Sciences, Faculty of Health Sciences, School of Public Health, The Health and Nutrition Innovative International Research Center, Ben-Gurion University of the Negev, P.O. Box 653, Beer-Sheva, 8410501, Israel.
Noa Ebstein KaramaniDepartment of Epidemiology, Biostatistics and Community Health Sciences, Faculty of Health Sciences, School of Public Health, The Health and Nutrition Innovative International Research Center, Ben-Gurion University of the Negev, P.O. Box 653, Beer-Sheva, 8410501, Israel.
Yoash ChassidimDepartment of Engineering, Sapir Academic College, Shaar Hanegev, Israel.
Ilan ShelefSoroka University Medical Center, Beer-Sheva, Israel.
Assaf RudichDepartment of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Uri YoelSoroka University Medical Center, Beer-Sheva, Israel.
Gal Ben-ArieSoroka University Medical Center, Beer-Sheva, Israel.
Hila ZelichaDepartment of Epidemiology, Biostatistics and Community Health Sciences, Faculty of Health Sciences, School of Public Health, The Health and Nutrition Innovative International Research Center, Ben-Gurion University of the Negev, P.O. Box 653, Beer-Sheva, 8410501, Israel.
Anat Yaskolka MeirDepartment of Epidemiology, Biostatistics and Community Health Sciences, Faculty of Health Sciences, School of Public Health, The Health and Nutrition Innovative International Research Center, Ben-Gurion University of the Negev, P.O. Box 653, Beer-Sheva, 8410501, Israel.
Gal TsabanDepartment of Epidemiology, Biostatistics and Community Health Sciences, Faculty of Health Sciences, School of Public Health, The Health and Nutrition Innovative International Research Center, Ben-Gurion University of the Negev, P.O. Box 653, Beer-Sheva, 8410501, Israel.
Carmi BartalBriuta Care Medical Center, Beer-Sheva, Israel.
Matthias BlüherHelmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany.
Michael StumvollDepartment of Medicine, University of Leipzig, Leipzig, Germany.
Uta CeglarekInstitute of Laboratory Medicine, University of Leipzig Medical Center, Leipzig, Germany.
Berend IsermannInstitute of Laboratory Medicine, University of Leipzig Medical Center, Leipzig, Germany.
Lu QiDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Meir J StampferDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Frank B HuDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Iris ShaiDepartment of Epidemiology, Biostatistics and Community Health Sciences, Faculty of Health Sciences, School of Public Health, The Health and Nutrition Innovative International Research Center, Ben-Gurion University of the Negev, P.O. Box 653, Beer-Sheva, 8410501, Israel. irish@bgu.ac.il.

Funding

Deutsche Forschungsgemeinschaft Germany's Excellence Strategy - EXC-3105/1 - 533765739
6 · The paper itself

Abstract

backgroundIt remains unclear whether reengaging in lifestyle weight loss interventions is effective for the long-term.

methodsWe conducted the CENTRAL (trial 1, T1) lifestyle weight-loss trial in 2012-2014, and the DIRECT-PLUS (trial 2, T2) weight-loss trial in 2017-2018. All participants were invited for follow-up in 2022-2024 to assess weight, metabolic biomarkers, and fat depots via magnetic-resonance-imaging (MRI) five years after the second trial.

resultsThe analysis included 572 trial observations contributed by 480 participants; of these, 388 participated in one of the two trials and 92 participated in both (T1 + T2 rejoiners). At follow-up, 384/480 (80%) were re-evaluated, including 76/92 (83%) rejoiners. In T1, participants who participated once and those who later rejoined T2 exhibited similar responses to their first intervention, including comparable weight-loss (-3.3% vs. -3.4%; FDR = 0.93). However, T1 + T2 rejoiners began their second intervention with a similar baseline BMI to their first (31.8 kg/m

conclusionsDespite an attenuated weight-loss response, repeated engagement in a structured lifestyle intervention yields meaningful long-term impacts with sustainable metabolic benefits.

trial registrationCENTRAL (Clinical-trials-identifier:NCT01530724); DIRECT-PLUS (Clinical-trials-identifier:NCT03020186).

Indexed as

ObesityWeight LossWeight Reduction ProgramsAdultFemaleFollow-Up StudiesHumansLife StyleMagnetic Resonance ImagingMaleMiddle AgedLifestyleMRIRandomized clinical trialVisceral adipose tissueWeight cyclingWeight-loss

Identifiers

PMID41612310
PMCPMC12930622

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.