ArticleAnnals of biomedical engineering2026
Modeling Red Blood Cell Deformation at Supraphysiological Strain Rates Using a Droplet Framework.
Article in Annals of biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Red blood cell deformation in a microfluidic sudden expansion at supraphysiological strain rates.Biophysical journal · 2026Article
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Authors and funding
3 authors.
Funding
Abstract
purposeHemolysis remains a concern in mechanical circulatory support devices (MCSDs). Capturing flow-induced red blood cell (RBC) deformation is important to improve these technologies. Deformation models that are feasible for macroscale MCSD flows have not been calibrated with human RBC deformation data across multiple conditions. The purpose of this study is to modify and test a droplet deformation model that is applicable for MCSD flows for predicting human RBC deformation in silico.
methodsIn vitro human RBC deformation is studied in microfluidic flows in two suspension viscosities (2.05 and 4.17 cP) at MCSD relevant strain rates (5,000 - 200,000 s
resultsThe calibrated model reproduces the unique RBC deformation behaviors observed in shear and extensional flows across a range of conditions. In silico shear deformation index data have mean absolute error (MAE) ≤ 0.15 compared to in vitro results for both viscosity conditions from 5,000 to 200,000 s
conclusionThe model adaptations successfully produce accurate RBC deformation results at MCSD relevant strain rates for two flow types and two suspension viscosities. The strengths of the model are in relatively high velocity gradient magnitudes and/or suspension viscosities where RBCs emulate liquid droplets.
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