ArticleClinical neuroradiology2026
Role of Advanced Multimodality Synthetic MRI and Dynamic Contrast-Enhanced MRI Derived Parameters in the Differentiating Neurocysticercosis and Tuberculomas.
Article in Clinical neuroradiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeRing-enhancing lesions (RELs) of the brain are frequently encountered but often pose diagnostic challenges. In tropical countries like India, neurocysticercosis (NCC) and tuberculomas are among the most common causes of intracranial RELs. Accurately distinguishing between the two is critical for appropriate treatment. To our knowledge, no prior study has combined synthetic MRI-derived parameters with DCE-MRI metrics to address this specific diagnostic dilemma. Out objective is to assess the diagnostic utility of relaxometry metrics from synthetic MRI, magnetization transfer ratio (MTR), and the volume transfer constant (K-trans) from dynamic contrast-enhanced (DCE) MRI in differentiating NCC from tuberculomas.
methodsThis prospective study included 53 patients with ring-enhancing brain lesions (24 NCC, 29 tuberculomas). All underwent conventional MRI, synthetic MRI, MT imaging, and DCE-MRI. Quantitative parameters (R1, R2, proton density, MTR, and K‑trans) were extracted from the lesion core, wall, and surrounding edema and analyzed using non-parametric statistical tests.
resultsTuberculomas demonstrated significantly higher pre-contrast R1 and R2 values in the core than NCC. A core R2 cutoff of ≤ 15.90 s⁻
conclusionSynthetic MRI-derived relaxometry and MTR provide objective, quantitative biomarkers to differentiate NCC from tuberculomas. The pre-contrast core R2 value emerged as the most discriminative parameter, enhancing diagnostic accuracy and supporting informed clinical decision-making.
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