Evidence map›Paper›PMID 41612038›Full record

ArticlePediatric nephrology (Berlin, Germany)2026

Early postnatal changes in serum creatinine from birth to peak and subsequent decline in preterm neonates.

Wataru Shimabukuro, Tomohide Yoshida, Tomoki Akamine, Kohei Shimada, Mayumi Tsukayama, Shogo Nakada, Kazuya Hamada, Noriko Kinjo, Koichi Nakanishi

Abstract read
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In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wataru ShimabukuroDepartment of Child Health and Welfare (Pediatrics), Graduate School of Medicine, University of the Ryukyus, 1076 Kiyuna, Ginowan, Okinawa, 901-2720, Japan.
Tomohide YoshidaDepartment of Child Health and Welfare (Pediatrics), Graduate School of Medicine, University of the Ryukyus, 1076 Kiyuna, Ginowan, Okinawa, 901-2720, Japan.
Tomoki AkamineDepartment of Child Health and Welfare (Pediatrics), Graduate School of Medicine, University of the Ryukyus, 1076 Kiyuna, Ginowan, Okinawa, 901-2720, Japan.
Kohei ShimadaDepartment of Child Health and Welfare (Pediatrics), Graduate School of Medicine, University of the Ryukyus, 1076 Kiyuna, Ginowan, Okinawa, 901-2720, Japan.
Mayumi TsukayamaDepartment of Child Health and Welfare (Pediatrics), Graduate School of Medicine, University of the Ryukyus, 1076 Kiyuna, Ginowan, Okinawa, 901-2720, Japan.
Shogo NakadaDepartment of Child Health and Welfare (Pediatrics), Graduate School of Medicine, University of the Ryukyus, 1076 Kiyuna, Ginowan, Okinawa, 901-2720, Japan.
Kazuya HamadaDepartment of Child Health and Welfare (Pediatrics), Graduate School of Medicine, University of the Ryukyus, 1076 Kiyuna, Ginowan, Okinawa, 901-2720, Japan.
Noriko KinjoDepartment of Child Health and Welfare (Pediatrics), Graduate School of Medicine, University of the Ryukyus, 1076 Kiyuna, Ginowan, Okinawa, 901-2720, Japan.
Koichi NakanishiDepartment of Child Health and Welfare (Pediatrics), Graduate School of Medicine, University of the Ryukyus, 1076 Kiyuna, Ginowan, Okinawa, 901-2720, Japan. knakanis@cs.u-ryukyu.ac.jp.ORCID http://orcid.org/0000-0001-8681-9129

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn preterm neonates, the postnatal course of serum creatinine (sCr) is influenced by maternal sCr levels and physiological changes. While transient postnatal increases have been reported, the relationship between the initial value at birth (Cr

methodsAmong 467 eligible preterm neonates admitted to neonatal intensive care unit, after excluding those with conditions or treatments affecting circulatory dynamics, the postnatal day of peak sCr was determined according to gestational age. Among these, 225 neonates with available Cr

resultsThe sCr peak occurred on day 2 in neonates with gestational age ≤ 29 weeks and on day 1 in neonates with gestational age ≥ 30 weeks. Simple regression revealed a significant correlation between Cr

conclusionsNeonatal sCr levels change during the early postnatal period, and the regression analysis identified a balance point at 0.95 mg/dL. These findings may aid interpretation of sCr changes when assessing acute kidney injury in preterm neonates.

Indexed as

Acute Kidney InjuryCreatinineInfant, PrematureFemaleGestational AgeHumansInfant, NewbornIntensive Care Units, NeonatalMaleCreatinineAcute kidney injuryKidney functionPostnatal adaptationPreterm neonateSerum creatinine

Identifiers

PMID41612038

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.