Evidence map›Paper›PMID 41612030›Full record

SynthesisEuropean journal of pediatrics2026

Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in asthmatic children: a systematic review with meta-analysis.

Alireza Sharifi, Reza Rahbar, Tregony Simoneau, Maryam Roham, Maryam Yaghoubi Hamgini, Shahram Seyedi, Samad Samadizadeh, Paria Ghasemi Boroumand, Mohaddeseh Zojaji, Shaghayegh Rahmanifar and 2 more

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alireza SharifiOtorhinolaryngology Research Center, Department of Otolaryngology-Head and Neck Surgery, Amir A'lam Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Reza RahbarDepartment of Otolaryngology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Tregony SimoneauDepartment of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Maryam RohamDepartment of Infectious Diseases, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Maryam Yaghoubi HamginiENT and Head and Neck Research Center and Department, The Five Senses Health Institute, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Shahram SeyediDepartment of Microbiology and Immunology, School of Medicine, Islamic Azad University, Tehran, Iran.
Samad SamadizadehDepartment of Oral and Maxillofacial Surgery, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
Paria Ghasemi BoroumandDepartment of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Mohaddeseh ZojajiDigestive Diseases Research Centre, Tehran University of Medical Sciences, Tehran, Iran.
Shaghayegh RahmanifarDepartment of Biomedical Engineering, School of Paramedical Sciences, Islamic Azad University-Science and Research Branch, Tehran, Iran.
Mohammad E GhaffariDepartment of Epidemiology and Biostatistics, Faculty of Health, Qom University of Medical Sciences, Qom, Iran.
Abotaleb Mohammadi-BrenjeganiClinical Research Development Unit, Hazrat-e Fateme Masoumeh Hospital, Qom University of Medical Sciences, Imam Street, P.O Box: 37185-34588, Qom, Iran. sh.ali.reza.ent@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to compare neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) between asthmatic and healthy children and to investigate the predictive role of PLR and NLR for asthma exacerbation. Web of Science, PubMed, Embase, Scopus, Cochrane Central Register of Controlled Trials, Google Scholar, and Medline were systematically searched up to August 2025. The search strategy was described by a combination of relevant medical subheadings (MeSH) and keywords. Eligible English language studies were reviewed, and their quality was appraised. This review followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A total of 13 studies, including 15,250 individuals, met the inclusion criteria. Asthmatic children had significantly higher NLR (SMD 0.852) and PLR (SMD 0.412) than the control group (P-value < 0.05). Exacerbated children had higher NLR (MD 2.5, P-value < 0.05) and PLR (MD 33.62, P-value > 0.05) at presentation compared to after 3 months follow-up. NLR with a cut-off of 1.738 (accuracy of 88%) and PLR with a cut-off of 128.15 (accuracy of 69.8%) can predict exacerbation in asthmatic pediatrics. Also, NLR with a cut-off of 1.335 (accuracy of 76.5%) can distinguish asthmatic from healthy children.

conclusionThis systematic review discovered that PLR and NLR are increased in asthmatic children, and any changes in clinical situation such as superinfection and exacerbation can change their level. Moreover, NLR and PLR can predict exacerbation, and NLR can even distinguish asthmatic from healthy children. WHAT IS KNOWN: • Asthma is diagnosed by classic methods such as spirometry, which cannot be used in younger children and cannot predict exacerbation. • A vital role in the inflammatory orchestra of asthma is played by activation of mast cells, which is mediated by a variety of markers, including neutrophils, platelets, lymphocytes, and macrophages. WHAT IS NEW: • Mean PLR and NLR are increased in asthmatic children, and any changes in clinical situation such as superinfection and exacerbation can change their level. • NLR and PLR can predict exacerbation, and NLR can even distinguish asthmatic from healthy children.

Indexed as

AsthmaBlood PlateletsLymphocytesNeutrophilsChildHumansLeukocyte CountLymphocyte CountPlatelet CountAsthmaExacerbationNeutrophil-to-lymphocyte ratioPediatricsPlatelet-to-lymphocyte ratioPrediction

Identifiers

PMID41612030

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.