SynthesisLangenbeck's archives of surgery2026
Effect of cyanoacrylate-based glue on postoperative leak and bleeding after pancreatectomy and sleeve gastrectomy: a systematic review and meta-analysis.
Synthesis in Langenbeck's archives of surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
13 authors.
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Abstract
aimsTo investigate effect of cyanoacrylate-based glue on postoperative leak and bleeding after pancreatectomy and sleeve gastrectomy.
methodsA PRISMA-compliant systematic review and meta-analysis using random effects modelling was performed including studies investigating effect of cyanoacrylate-based glue on postoperative leak and bleeding in patients undergoing pancreatectomy and sleeve gastrectomy. Proportion meta-analysis and comparison meta-analysis were modelled to evaluate the outcomes.
resultsAnalysis of 1800 patients from nine studies showed no difference in the risk of postoperative leak between the cyanoacrylate-based glue and no glue groups in all pancreatic resections (OR: 1.26, p = 0.700), in pancreaticoduodenectomy with total duct occlusion (OR: 3.21, p = 0.360), in pancreaticoduodenectomy with pancreaticojejunostomy (OR: 0.42, p = 0.550), in distal pancreatectomy (OR: 1.50, p = 0.330), and in sleeve gastrectomy (OR: 0.14, p = 0.07). Moreover, there was no difference in the risk of postoperative bleeding between the cyanoacrylate-based glue and no glue groups in all pancreatic resections (OR: 1.44, p = 0.460), in pancreaticoduodenectomy with total duct occlusion (OR: 0.35, p = 0.520), in pancreaticoduodenectomy with pancreaticojejunostomy (OR: 2.75, p = 0.080), in distal pancreatectomy (OR: 0.72, p = 0.670), and in sleeve gastrectomy (OR: 0.37, p = 0.14). Cyanoacrylate-based glue did not reduce the risk of grade A (OR: 1.16, p = 0.82), grade B (OR: 1.29, p = 0.460), and grade C (OR: 0.36, 3.16, p = 0.360) postoperative pancreatic fistula.
conclusionsLevel 2 evidence with moderate certainty suggests that cyanoacrylate-based glue does not reduce the risk of postoperative leak and bleeding after pancreatectomy and sleeve gastrectomy. More studies with larger sample sizes are required to exclude type 2 error.
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