Evidence map›Paper›PMID 41612025›Full record

ArticleNature neuroscience2026

Corticothalamic communication for action coordination in a skilled motor behavior.

Yi Li, Xu An, Patrick J Mulcahey, Yongjun Qian, X Hermione Xu, Shengli Zhao, Hemanth Mohan, Shreyas M Suryanarayana, Ludovica Bachschmid-Romano, Nicolas Brunel and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Yi LiDepartment of Neurobiology, Duke University, Durham, NC, USA.ORCID http://orcid.org/0000-0001-8025-1552
Xu AnDepartment of Neurobiology, Duke University, Durham, NC, USA.
Patrick J MulcaheyDepartment of Neurobiology, Duke University, Durham, NC, USA.
Yongjun QianDepartment of Neurobiology, Duke University, Durham, NC, USA.ORCID http://orcid.org/0000-0002-2696-6730
X Hermione XuDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Shengli ZhaoDepartment of Neurobiology, Duke University, Durham, NC, USA.
Hemanth MohanDepartment of Neurobiology, Duke University, Durham, NC, USA.
Shreyas M SuryanarayanaDepartment of Neurobiology, Duke University, Durham, NC, USA.ORCID http://orcid.org/0000-0001-9122-0399
Ludovica Bachschmid-RomanoDepartment of Neurobiology, Duke University, Durham, NC, USA.
Nicolas BrunelDepartment of Neurobiology, Duke University, Durham, NC, USA.
Ian Q WhishawDepartment of Neuroscience, Canadian Centre for Behavioural Research, University of Lethbridge, Lethbridge, Alberta, Canada.
Z Josh HuangDepartment of Neurobiology, Duke University, Durham, NC, USA. josh.huang@duke.edu.ORCID http://orcid.org/0000-0003-0592-028X

Funding

Medical Scientist Training Program Training GrantT32GM145449 · NIGMS · DUKE UNIVERSITY · PI Christopher D Kontos · 2022 to 2026
$6.6M
NIGMS NIH HHS T32 GM145449U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) U19MH114823-01
6 · The paper itself

Abstract

The coordination of forelimb and orofacial movements to compose an ethological reach-to-consume behavior likely involves neural communication across brain regions. Leveraging wide-field imaging and photoinhibition to survey across the cortex, we identified a cortical network and a high-order motor area (the central region of the secondary motor cortex (MOs-c)), which coordinate action progression in a mouse reach-and-withdraw-to-drink (RWD) behavior. Electrophysiology and photoinhibition across multiple projection neuron types within the MOs-c revealed differential contributions of pyramidal tract and corticothalamic (CT

Indexed as

Motor CortexMotor SkillsPsychomotor PerformanceThalamusAnimalsMaleMiceNeural PathwaysNeuronsPyramidal Tracts

Identifiers

PMID41612025

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.