ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2026
Genetic evidence for POR-mediated ferroptosis in lung cancer prevention: a causal role of granulocyte modulation.
Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundCytochrome P450 oxidoreductase (POR) plays a vital role in ferroptosis within lung cancer. A potential link exists between ferroptosis-related genes and immune cell activity. This research aimed to confirm whether POR influences lung cancer by modulating immune cells.
methodsGenetic variants of the POR gene were identified from lung tissue expression quantitative trait loci (eQTL) data using single nucleotide polymorphisms (SNPs). A genome-wide study of 40,187 Europeans found variants linked to lung cancer. Mediation analysis on 731 immunophenotypes was done to assess their mediating effect on the POR gene-lung cancer relationship.
resultsThis study identified four SNPs for further investigation. Mediation analysis suggested that three immune cell traits might mediate the effect of POR on lung cancer, with CD11c on granulocyte showing a clear mediation effect (β
conclusionsOur analysis revealed that increased expression in the POR gene was linked to a lower genetically predicted risk of lung cancer, with a significant mediation effect by the CD11c on granulocyte.
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